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Special Issue "Molecular Advances in Microbial Metabolism"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 20 November 2021.

Special Issue Editors

Prof. Dr. Rosa María Martínez-Espinosa
E-Mail Website
Guest Editor
Department of Agrochemistry and Biochemistry, Faculty of Science, University of Alicante, Ap. 99, 03080 Alicante, Spain
Interests: microbial biochemistry and molecular biology; N-cycle, enzymes; archaea; natural carotenoids; bioremediation
Special Issues and Collections in MDPI journals
Dr. Carmen Lucía Pire-Galiana
E-Mail Website
Guest Editor
Department of Agrochemistry and Biochemistry, Faculty of Science, University of Alicante, San Vicente del Raspeig, Spain
Interests: archaeal; denitrification; nitrogen cycle
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Microbial metabolism is one of the main driving forces behind the development and maintenance of the biosphere. Due to the relevance of these metabolic pathways, this Special Issue focuses on molecular mechanisms underlying microbial metabolism, not only to improve the knowledge around processes carried out by microbes to obtain energy and nutrients to live and reproduce, but also to shed light on microbial evolution and potential applications of metabolic pathways carried out by microbes in biotechnology and industrial processes. This multidisciplinary topic comprises several disciplines, such as microbiology, molecular biology, genetics, chemistry, microbial ecology, biochemistry, biophysics, and all omics-based sciences which offer insight into the impact that modern technologies have on microbiological research today. Original investigations as well as concise review manuscripts from experts in the relevant research fields will be considered for publication.

Prof. Dr. Rosa María Martínez-Espinosa
Dr. Carmen Lucía Pire-Galiana
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • central metabolism
  • secondary metabolism
  • ancient molecules
  • evolution
  • systems biology
  • aerobic metabolism
  • anaerobic metabolism
  • fermentation

Published Papers (2 papers)

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Research

Article
Na+-Coupled Respiration and Reshaping of Extracellular Polysaccharide Layer Counteract Monensin-Induced Cation Permeability in Prevotella bryantii B14
Int. J. Mol. Sci. 2021, 22(19), 10202; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms221910202 - 22 Sep 2021
Viewed by 284
Abstract
Monensin is an ionophore for monovalent cations, which is frequently used to prevent ketosis and to enhance performance in dairy cows. Studies have shown the rumen bacteria Prevotella bryantii B14 being less affected by monensin. The present study aimed to reveal [...] Read more.
Monensin is an ionophore for monovalent cations, which is frequently used to prevent ketosis and to enhance performance in dairy cows. Studies have shown the rumen bacteria Prevotella bryantii B14 being less affected by monensin. The present study aimed to reveal more information about the respective molecular mechanisms in P.bryantii, as there is still a lack of knowledge about defense mechanisms against monensin. Cell growth experiments applying increasing concentrations of monensin and incubations up to 72 h were done. Harvested cells were used for label-free quantitative proteomics, enzyme activity measurements, quantification of intracellular sodium and extracellular glucose concentrations and fluorescence microscopy. Our findings confirmed an active cell growth and fermentation activity of P.bryantii B14 despite monensin concentrations up to 60 µM. An elevated abundance and activity of the Na+-translocating NADH:quinone oxidoreductase counteracted sodium influx caused by monensin. Cell membranes and extracellular polysaccharides were highly influenced by monensin indicated by a reduced number of outer membrane proteins, an increased number of certain glucoside hydrolases and an elevated concentration of extracellular glucose. Thus, a reconstruction of extracellular polysaccharides in P.bryantii in response to monensin is proposed, which is expected to have a negative impact on the substrate binding capacities of this rumen bacterium. Full article
(This article belongs to the Special Issue Molecular Advances in Microbial Metabolism)
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Article
Integration of Transcriptome and Metabolome Reveals the Genes and Metabolites Involved in Bifidobacterium bifidum Biofilm Formation
Int. J. Mol. Sci. 2021, 22(14), 7596; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147596 - 15 Jul 2021
Viewed by 548
Abstract
Bifidobacterium bifidum strains, an important component of probiotic foods, can form biofilms on abiotic surfaces, leading to increased self-resistance. However, little is known about the molecular mechanism of B. bifidum biofilm formation. A time series transcriptome sequencing and untargeted metabolomics analysis of both [...] Read more.
Bifidobacterium bifidum strains, an important component of probiotic foods, can form biofilms on abiotic surfaces, leading to increased self-resistance. However, little is known about the molecular mechanism of B. bifidum biofilm formation. A time series transcriptome sequencing and untargeted metabolomics analysis of both B. bifidum biofilm and planktonic cells was performed to identify key genes and metabolites involved in biofilm formation. Two hundred thirty-five nonredundant differentially expressed genes (DEGs) (including vanY, pstS, degP, groS, infC, groL, yajC, tadB and sigA) and 219 nonredundant differentially expressed metabolites (including L-threonine, L-cystine, L-tyrosine, ascorbic acid, niacinamide, butyric acid and sphinganine) were identified. Thirteen pathways were identified during the integration of both transcriptomics and metabolomics data, including ABC transporters; quorum sensing; two-component system; oxidative phosphorylation; cysteine and methionine metabolism; glutathione metabolism; glycine, serine and threonine metabolism; and valine, leucine and isoleucine biosynthesis. The DEGs that relate to the integration pathways included asd, atpB, degP, folC, ilvE, metC, pheA, pstS, pyrE, serB, ulaE, yajC and zwf. The differentially accumulated metabolites included L-cystine, L-serine, L-threonine, L-tyrosine, methylmalonate, monodehydroascorbate, nicotinamide, orthophosphate, spermine and tocopherol. These results indicate that quorum sensing, two-component system and amino acid metabolism are essential during B. bifidum biofilm formation. Full article
(This article belongs to the Special Issue Molecular Advances in Microbial Metabolism)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title 1: The phosphate stimulon of Streptomyces lividans and its alteration in Streptomyces coelicolor

Title 2: Understanding gene regulation in denitrification driven by haloarchaea

Title 3: Na+-coupled respiration and reshaping of extracellular polysaccharide layer counteract monensin-induced cation permeability in Prevotella bryantii B14

 
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