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Special Issue "Molecular Interactions between Cancer Cells and Tumor Microenvironment 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editors

Prof. Dr. Piotr Dzięgiel
E-Mail Website
Guest Editor
Division of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, 50-368 Wroclaw, Poland
Interests: cancer biology; cell proliferation; cancer biomarkers; tumor microenvironment; immunohistochemistry; histology
Special Issues and Collections in MDPI journals
Dr. Katarzyna Nowińska
E-Mail Website
Guest Editor
Division of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, 50-368 Wroclaw, Poland
Interests: cancer-associated fibroblasts; tumor microenvironment; cell proliferation; cancer immunotherapy; histology

Special Issue Information

Dear Colleagues,

The complexity and dynamic nature of the tumor microenvironment (TME) and interaction between stromal cells and cancer cells still remains a challenge for the pre- and clinical studies of tumors. The TME has been recognized as a factor influencing the treatment resistance of radiotherapy and chemotherapy. TME components, such as cancer-associated fibroblasts (CAFs), tumor-associated macrophages (TAMs) or tumor-infiltrating lymphocytes (TILs), are associated with tumor biology and patient prognosis. They are mostly involved in cancer cell proliferation, changes in cancer cell metabolism, angiogenesis, metastasis formation or epithelial to mesenchymal transition (EMT). TME promotes tumorigenesis by secreting cytokines and initiating extracellular matrix (ECM) remodeling. ECM proteins also play an important role in the regulation of cancer cell biology, metastatic potential and patient outcome. In this 2nd Special Issue, we will discuss the biology of TME components and their interactions with cancer cells, as well as their impact on the effectiveness of therapy.

Prof. Dr. Piotr Dzięgiel
Dr. Katarzyna Nowińska
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer cells
  • tumor microenvironment
  • TME
  • cancer-associated fibroblasts
  • tumor-infiltrating lymphocytes
  • tumor-associated macrophages
  • epithelial to mesenchymal transition
  • extracellular matrix
  • metastasis
  • cell proliferation

Published Papers (1 paper)

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Review

Review
Tumor-Associated Macrophages: Combination of Therapies, the Approach to Improve Cancer Treatment
Int. J. Mol. Sci. 2021, 22(13), 7239; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22137239 - 05 Jul 2021
Viewed by 1035
Abstract
Macrophages are one of the most important cells of the innate immune system and are known for their ability to engulf and digest foreign substances, including cellular debris and tumor cells. They can convert into tumor-associated macrophages (TAMs) when mature macrophages are recruited [...] Read more.
Macrophages are one of the most important cells of the innate immune system and are known for their ability to engulf and digest foreign substances, including cellular debris and tumor cells. They can convert into tumor-associated macrophages (TAMs) when mature macrophages are recruited into the tumor microenvironment. Their role in cancer progression, metastasis, and therapy failure is of special note. The aim of this review is to understand how the presence of TAMs are both advantageous and disadvantageous in the immune system. Full article
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