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Special Issue "Mechanisms of Molecular Motor Triggered Cell Motility"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 November 2021.

Special Issue Editor

Dr. Takeshi Sakamoto
E-Mail Website
Guest Editor
Department of Physiology, School of Medicine, Wayne State University, Detroit, MI 48202, USA
Interests: cell migration; cell mechanics; myosin; actin formation; kinesin; Dynein; traction force; cancer cell; myosin ATPase

Special Issue Information

Dear Colleagues,

Cell motility is a fundamental process for the wellbeing of an organism. This biological process ensured vital physiological functions to be performed. For example, wound healing, immune response, metastasi,s and embryo developments are recently good examples. Cell motilities rely on the coordination of cellular proteins and structures, involving cytoskeleton, actin and microtubules, myosin and kinesin, and focal adhesion proteins. Cells in motion are polarized, forming a leading edge pointing in the direction of migration and a trailing edge at the other end. At the leading edge, actin filaments polymerized into network structures similar tree branches and push the membrane forward. Behind the polymerization region, clusters of myosin binds to the actin network. As the lamellipodium protrudes and touch down on the substrate, the focal adhesion proteins on the cell membrane will anchor themselves on the substrate integrins to provide cell traction. Although these are known as a basic cell mechanis, the function of molecular motors found wide varety and influencing each other.

This Special Issue aims to be the first comprehensive systematic collection of studies on this aspect, accepting original research and review articles including but not limited to the following topics:

  • Task of molecular motor in cell migration;
  • Actomyosin function in cell traction force;
  • Kinesin motor in cell migration;
  • Mechanical model study, including computer simulation that studies molecular motors of cell migration.

Dr. Takeshi Sakamoto
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cell migration
  • cell mechanics
  • myosin
  • actin formation
  • kinesin
  • dynein
  • traction force
  • cancer cell
  • myosin ATPase

Published Papers

This special issue is now open for submission.
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