Special Issue "Molecular Mechanisms of Muscular Dystrophy"
Deadline for manuscript submissions: 31 October 2021.
Interests: insulin; GABA; behavior; anterior cingulate cortex; molecular imaging; MRI; RNA; myotonic dystrophy; obsessive compulsive disorder; autism
Muscular dystrophies constitute a heterogeneous set of diseases primarily characterized by muscle weakness. These are often multisystem in nature and present with effects primarily on the muscular, cardiac, and central nervous systems. These diverse muscular dystrophies encompass those with myotonic (both type I and II), congenital and limb-girdle forms but also include the Duchenne, Becker, and facioscapulohumeral (FSHD) muscular dystrophies. A range of genetic mutations and splicing events across these muscular dystrophies prevent optimal protein production and disrupt effective cellular communication. Current research across muscular dystrophies implicates a role for regulatory mechanisms at the level of both transcriptomic and epigenomic events in the disease phenotype and suggests that the severity of disease is not solely dictated by events related to the underlying genetic mutation. In order to further categorize the molecular substrates underlying these diverse muscular dystrophies, their severity and potential treatment approaches, translational approaches in both cellular and animal models as well as humans are needed. This Special Issue will highlight these molecular substrates and seek to clarify novel avenues deserving of follow-up with high clinical utility.
Dr. Jeffrey Glennon
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- Type 1 and 2 myotonic dystrophy
- Facioscapulohumeral (FSHD) muscular dystrophy
- Duchenne muscular dystrophy
- Cellular models
- Animal models