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Special Issue "Progress on Multidrug Resistance Mechanisms in Cancer"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 September 2021.

Special Issue Editor

Prof. Dr. Chung-Pu Wu
E-Mail Website
Guest Editor
Department of Physiology and Pharmacology, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan,Tao-Yuan 333, Taiwan
Interests: Multidrug Resistance Mechanisms; ATP-binding Cassette Proteins; Protein Kinase Inhibitors; Medicinal Chemistry; Natural Products Chemistry

Special Issue Information

Dear Colleagues,

A high proportion of cancer patients will develop multidrug resistance (MDR) during the course of chemotherapy, and they will no longer be responsive to anticancer agents that are structurally and functionally distinctive. Multiple molecular mechanisms are known to contribute to the development of multidrug resistance in cancer, including but not limited to reduced drug uptake and increased drug efflux, enhanced cellular repair mechanisms, and alterations of drug metabolism or drug targets. These resistance mechanisms can work both independently and collaboratively. In the past few years, new therapeutic targets and drug resistance mechanisms have been discovered; innovative therapeutic approaches and interventions have also been experimented with to overcome these resistance mechanisms. This Special Issue on “Progress in Multidrug Resistance Mechanisms in Cancer” invites researchers to contribute original research articles, review articles, and short communications related to all aspects of drug development and therapeutic approaches against multidrug-resistant cancers, as well as molecular mechanisms of multidrug resistance in cancer.

Prof. Chung-Pu Wu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cancer
  • multidrug resistance
  • mechanisms of acquired drug resistance
  • anticancer drugs
  • drug development
  • drug discovery
  • combined therapy
  • translational medicine
  • therapeutic targets

Published Papers

This special issue is now open for submission.
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