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Special Issue "NK Cells, Immune Response in Pathology and Cancer"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 31 January 2022.

Special Issue Editors

Dr. Isabel Legaz Pérez
E-Mail Website
Guest Editor
Department of Legal and Forensic Medicine, Biomedical Research Institute (IMIB), Regional Campus of International Excellence "Campus Mare Nostrum", Faculty of Medicine, University of Murcia, Murcia, Spain
Interests: forensic sciences; legal medicine; biochemistry; proteomics; genetics; biomedicine; human toxicology; immunology; NK cells
Special Issues, Collections and Topics in MDPI journals
Dr. Manuel Muro
E-Mail Website
Guest Editor
1. Head of Immunology Service and Director of Regional Laboratory of Histocompatibility and Transplant Immunology, Clinical University Hospital “Virgen de la Arrixaca”, El Palmar, 30120 Murcia, Spain
2. Biomedical Research Institute of Murcia (IMIB), Murcia, Spain
Interests: transplant immunology; proteomics; inmunogenetics; acute rejection; immune response; tolerance; innate immunity; NK cells
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Numerous studies relate the role of different immune system biomarkers related to susceptibility, prognostic and predictive factors in several human solid and liquid tumors in humans. However, little is known about innate immune mechanisms that allow a tumor cell to escape from immune control systems. 

The innate immune system is a highly dynamic system where different types of cells, ligands, and receptors are involved, including the spatial and temporal components, which are critical because they are associated with age, sex, and life habits interaction with toxics. From the clinical point of view, NK cells are essential for their role in detecting cancer. Besides, these cells present different types of receptors that allow modulating their activity. Most of these receptors tend to be highly polymorphic and tend to present high allelic variability, revealing different omic scenarios (genomic, transcriptomic, and proteomics) at the individual level, which searches for cause and effect even more difficult in individuals with tumors.
Given the enormous potential presented by NK analysis, there is a need to characterize, analyze and interpret the receptor and ligand as well as the mechanisms of action in different types of tumors, as well as to create solid and complete databases for full implementation in the clinical context, thus allowing the user to clarify the causes of carcinogenesis, metastasis, recurrence or to estimate the recurrence time, among other uses. Several studies point to a promising future for NK analysis in the different fields of clinical medical science, opening up an important new area of research.

Apart from their indisputable role in cancer, these cells and their cell receptors are also very important in the immune response to transplants, both of solid organs and hematopoietic transplants. The individual variation of the omic relationships of the NK cell could be of great help in determining the cause of heath and sickness.

Dr. Isabel Legaz Pérez
Dr. Manuel Muro
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cancer
  • NK cells
  • biomarkers
  • innate immune system

Published Papers

This special issue is now open for submission.
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