Special Issue "Nano-Strategies: The Future Medicine for Fighting Cancer Progression and Drug Resistance 2.0"
Deadline for manuscript submissions: 30 September 2021.
Interests: cancer research; cancer chemotherapy; molecular biology; cell biology; pharmacology; nanomedicine; drug discovery
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The administration of conventional antitumor therapy is the first choice in clinical practice for patients suffering from disseminated tumors. Unfortunately, the development of drug resistance and systemic toxicity often require the suspension of treatment and lead to tumor progression and patients’ deaths. Among the several strategies considered to counteract drug resistance, the encapsulation of the drugs into nanovectors appears very promising. Importantly, their capability demonstrated in protecting cargo makes nanodevices useful for the delivery of therapeutic nucleic acids, a field of research that has increased significantly in recent years. Despite numerous studies that have proved the efficacy of nanosystems in (i) carrying a large therapeutics “payload,” (ii) accommodating multiple drug molecules that simultaneously enable combinatorial cancer therapy and bypass well-known drug resistance mechanisms, and (iii) targeting specific cells/tissues through the multivalent targeting ligands, which yield high affinity and specificity, only a limited number of nanodevices have attained clinical success (e.g., Doxil and Abraxane). These features imply that additional efforts are required before nanomedicine supplants conventional drug delivery administration. In this Special Issue, we welcome contributions, reviews, and original articles focused on all the aspects embraced by nanostrategies and adopted for combating cancer progression and drug resistance.
Dr. Giovanni L. Beretta
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- Antitumor drugs
- Tumor progression
- Drug resistance
- Drug delivery