Special Issue "Connecting In Vitro, In Vivo, and Ex Vivo Studies in Neurodegenerative Diseases"
Deadline for manuscript submissions: 31 October 2021.
Interests: biophysics; amyloid formation; amyloid cytotoxicity; protein misfolding; amyloid- neuroinflammatory cascade; amyloid diagnostics and prognostics; neurodegenerative diseases
Neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and others, are age-related multifactorial pathologies, in which complex events lead to impairment of brain activity with cognitive disability as the main clinical hallmark. Amyloid cascade and neuroinflammation are their most obvious and closely interlinked pathological manifestations. The underlying cause of the amyloid cascade is the failure of specific peptides/proteins to adopt and retain their native structure, leading to self-assembly into amyloid oligomers and fibrils and growing amyloid burden. The amyloid conversion results in the loss of physiological function and gain of amyloid cytotoxicity. The latter is linked to derangement of both specific signalling pathways and several homeostatic cell functions. Basic science and clinical research have made extraordinary progress in the last two decades, providing insights into the mechanisms of pathological aggregation and in discovering new diagnostic tools and therapeutic options. Due to the biological complexity of diseases, the multidisciplinary approach may bridge the gap between experimental models and disease in patients. In this issue, the research linking in vitro, in vivo, and ex vivo studies are welcome to address this very complex and challenging problem, and shed light on the triggers, causes, mechanisms, and treatment of neurodegenerative diseases. We may not solve all problems but “wisdom begins in wonders” (Socrates).
Prof. Dr. Ludmilla A. Morozova-Roche
Dr. Igor A. Iashchishyn
Manuscript Submission Information
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- neurodegenerative disease
- amyloid mechanisms
- disease prevention
- disease cause