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Special Issue "Connecting In Vitro, In Vivo, and Ex Vivo Studies in Neurodegenerative Diseases"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editors

Prof. Dr. Ludmilla A. Morozova-Roche
E-Mail Website
Guest Editor
Department of Medical Biochemistry and Biophysics, Umea University, 90781 Umea, Sweden
Interests: biophysics; amyloid formation; amyloid cytotoxicity; protein misfolding; amyloid- neuroinflammatory cascade; amyloid diagnostics and prognostics; neurodegenerative diseases
Dr. Igor A. Iashchishyn
E-Mail Website
Guest Editor
Department of Medical Biochemistry and Biophysics, Umea University, Umea 90781, Sweden
Interests: biophysics; material science; reaction kinetics; atomic force microscopy; neuredegenerative diseases; amyloid formation

Special Issue Information

Dear Colleagues,

Neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and others, are age-related multifactorial pathologies, in which complex events lead to impairment of brain activity with cognitive disability as the main clinical hallmark. Amyloid cascade and neuroinflammation are their most obvious and closely interlinked pathological manifestations. The underlying cause of the amyloid cascade is the failure of specific peptides/proteins to adopt and retain their native structure, leading to self-assembly into amyloid oligomers and fibrils and growing amyloid burden. The amyloid conversion results in the loss of physiological function and gain of amyloid cytotoxicity. The latter is linked to derangement of both specific signalling pathways and several homeostatic cell functions. Basic science and clinical research have made extraordinary progress in the last two decades, providing insights into the mechanisms of pathological aggregation and in discovering new diagnostic tools and therapeutic options. Due to the biological complexity of diseases, the multidisciplinary approach may bridge the gap between experimental models and disease in patients. In this issue, the research linking in vitro, in vivo, and ex vivo studies are welcome to address this very complex and challenging problem, and shed light on the triggers, causes, mechanisms, and treatment of neurodegenerative diseases. We may not solve all problems but “wisdom begins in wonders” (Socrates).

Prof. Dr. Ludmilla A. Morozova-Roche
Dr. Igor A. Iashchishyn
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • neurodegenerative disease
  • Alzheimer’s
  • Parkinson’s
  • amyloid
  • neuroinflammation
  • models
  • amyloid mechanisms
  • cytotoxicity
  • disease prevention
  • disease cause

Published Papers

This special issue is now open for submission.
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