Dear Colleagues,

Neuroendocrine Neoplasms (NENs) are rare tumors that arise from the diffuse neuroendocrine system. Although NENs are usually considered rare neoplasms than non-neuroendocrine neoplasms, their incidence and prevalence is increased in the last decades, as reported by epidemiological studies. NENs are also very heterogeneous tumors both biologically and for their clinical behavior. Indeed, the management of these diseases requires a multidisciplinary team consisting of a wide range of members, such as: oncologists, endocrinologists, pathologists, nuclear medicine specialists, radiologists, and molecular biologists. Recently, many efforts have been done to shed light the biological mechanisms involved in the genesis and the evolution of this tumors, in order to provide novel approaches to their treatment. On the other hand, screening strategies and diagnostic tools have continually evolved allowing an early diagnosis and thus improving the clinical outcome. However, many other studies are ongoing and are expected. In this special issue, we will appreciate original studies and review articles that gather research on the novel discoveries about the molecular biology, genetic, epigenetic and signaling pathways of NENs that could offer real progresses in the management of diagnosis and therapeutic approach of NENs patients. The special issue will also encourage papers approaching biomolecular experiments performed as part of clinical studies.

Dr. Salvatore Tafuto
Guest Editor

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