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Special Issue "The Role of Neuroimmune Inflammation in Chemotherapy-Induced Side Effects"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 31 July 2021.

Special Issue Editors

Dr. Silvia Franchi
E-Mail Website
Guest Editor
Department of Pharmacological and Biomolecular Sciences; Università degli Studi di Milano
Interests: pain; cytokines; neuroinflammation; mood
Dr. Lorenzo Di Cesare Mannelli
E-Mail Website
Guest Editor
Universita degli Studi di Firenze, Florence, Italy
Interests: pharmacology; medicinal plants; chronic pain; nervous system pathologies and treatment; glia; cholinergic receptors; opioid receptors
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Chemotherapy has increased the survival rate in cancer patients; however, despite the undisputed benefits, antitumoral drugs cause a wide range of known and little-known side effects, such as chemotherapy-induced neuropathy (CIN), chemotherapy-induced cognitive impairment (CICI), and the development of mood alterations such as anxiety and depression. All of these complications seem to be independent of the antitumoral effect, are also common to newer antitumoral molecules, and are often connected to and dependent on each other. Emerging evidence indicates that neuroimmune inflammation at the peripheral and central nervous system level plays a pivotal role in the development of such complications. Infiltrated and resident immune cells or glial cells interact with the neuronal component, promoting a sensitization process and maladaptive plasticity that contribute to the progression of damage and finally result in clinical complications. In this scenario, both classic and newer biomolecules could represent novel pharmacological targets to counteract the development of chemotherapy-induced side effects but could also represent potential biomarkers to predict them.This Special Issue aims to collect recent findings regarding the role of neuroimmune inflammation in chemotherapy-induced side effects, identifying mechanisms and novel controlling networks or suggesting new potential pharmacological approaches to counteract or predict them.

Prof. Dr. Silvia Franchi
Prof. Dr. Lorenzo Di Cesare Mannelli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • neuroimmune inflammation
  • chemotherapy-induced side effects
  • neuropathy
  • chemobrain
  • mood
  • cytokines
  • chemokines
  • glia

Published Papers

This special issue is now open for submission.
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