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Special Issue "Neuroinflammation: From Molecular Mechanisms to Therapeutic Perspectives"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 31 May 2021.

Special Issue Editor

Prof. Dr. Marta Llansola
E-Mail Website
Guest Editor
Centro de Investigacion Principe Felipe, Valencia, Spain
Interests: Hepatic encephalopathy; neuroinflammation; cognitive impairment; cerebellum; hippocampus; motor coordination; cytokines; glutamate receptors; GABA transporters; microbiota metabolits

Special Issue Information

Dear Colleagues,

Diseases that involve the nervous system and different neuropsychiatric syndromes, including those simply associated with aging, are currently one of the great concerns in global health. There is no doubt that neuroinflammation is involved to a greater or lesser degree in most brain diseases, whether chronic, neurodegenerative, or involving acute brain damage, for a multitude of different causes. This means that knowing the different mechanisms involved in the appearance of neuroinflammation would be very useful to understand the mechanisms of the different alterations in brain function. Once the mechanisms are known in detail, a wide field of possible therapeutic targets will be opened, based on neuroinflammation processes, which undoubtedly must be developed to establish therapeutic strategies that can prevent or improve a multitude of brain diseases and symptoms, such as cognitive impairment (from mild to more severe), memory loss, motor impairment, mood, and even coma and death. This is necessary today in order to improve general health, given the high incidence of mental illnesses that affect the quality of life of many people, either due to illness or simply associated with aging.

The relationship between neuroinflammation and alterations in neurotransmission are still unknown, and it would be very important to advance the knowledge of these mechanisms in order to expand the therapeutic possibilities, since altered neurotransmission is the main basis of alterations in brain function, and therefore the cause of different neurological disorders.

The objective of this Special Issue is to update the knowledge about the mechanisms of neuroinflammation in different circumstances and the therapeutic implications that it entails—not only based on the mechanisms that lead to neuroinflammation, but also on how it interferes with brain mechanisms (mainly neurotransmission) to alter brain function.

Prof. Dr. Marta Llansola
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Neuroinflammation
  • Neurotransmission
  • Neurological disorders
  • Molecular mechanisms
  • Glia
  • Cytokines
  • Chemokines
  • Neurotransmitter receptors
  • Signal transduction
  • Therapeutic targets

Published Papers

This special issue is now open for submission.
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