Dear Colleagues,

The number of patients suffering from neurodegenerative diseases including the Alzheimer's Diseases (AD) and Parkinson's Diseases (PD) is ever increasing and it is becoming an important social issue that needs to be solved as soon as possible. Especially, finding the core pathology inducing these diseases are urgently needed to prevent that can help developing disease modifying drugs.

Evidences from recent research are showing that the dysfunction in the neurovascular unit (NVU) and influx of factors from peripheral system is one of the major driving forces in the neuroinflammation that eventually induces neurodegenerative diseases. This is changing the angle of viewpoint looking at the neurodegenerative diseases and may be a potential breakthrough to find a new concept of therapeutics. This emphasizes the importance of thorough and cutting edge research in this emerging field.

This Special Issue of the International Journal of Molecular Sciences entitled “Dysfunction in Neurovascular Unit, Neuroinflammation, and the Neurodegenerative diseases” aims to highlight the importance of the role of neuroinflammation triggered by dysregulation of the NVU in the development of neurodegenerative diseases and dissecting the mechanisms behind of it.

We welcome research articles that will improve the understanding in pathophysiological mechanisms of disruption of the NVU and its migration of peripheral factors correlated with various types of brain immune responses in the context of development of neurodegenerative. Moreover, we also recruit review article that discusses recent advances in the field that can provide information to audiences in the neurodegenerative field which would be helpful to understand the neurodegenerative diseases in a different angle.

Dr. Hyang-Sook Hoe
Dr. Do-Geun Kim
Guest Editors

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• Dysfunction of the Neurovascular Unit
• Peripheral blood factors
• Neuroinflammation
• Neurodegenerative Disease