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Special Issue "Neurolipids in Neurodegenerative Disorders"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 30 November 2021.

Special Issue Editor

Dr. Rafael Rodriguez-Puertas
E-Mail Website
Guest Editor
Universidad del País Vasco / Euskal Herriko Unibertsitatea
Interests: Neuropharmacology; neurolipids; cannabinoid; cholinergic; imaging mass spectrometry; Alzheimer’s disease; radioligand binding; neurodegeneration

Special Issue Information

The lipid molecules that constitute most of the dry mass of brain are mainly phospholipids (PL), sphingolipids (SL) and cholesterol, which are located at cellular membranes. During the last decade new analytical methods have been developed allowing the description, localization and identification of these lipid molecules. Accordingly, the super specialization of lipids in the brain is being uncovered, accounting for a wide range of functions, that include their known structural, metabolic and energetic metabolism, but also some lipid species are being identified as lipid mediators and signalling agents. These lipids with signalling activity reach their maximum level of specialization and diversity in the Central Nervous System (CNS), where they can act as neuromodulators or real neurotransmitters involved in the control of multiple physiological processes. These endogenous lipid-based signalling molecules constitute complete neurotransmitter systems and can be denominated as neurolipids (in a similar way to the term “neuropeptides”). The main sources of neurolipids are membrane lipid precursors which are mobilized by phospholipases, sphingomyelinases or different hydroxylases. The identified neurolipids would include endocannabinoids, lysophospholipids (LP), some free fatty acids, platelet activating factors, some sulfatides-derived neurolipids such as ceramide, ceramide 1-phosphate, sphingosine, sphingosine 1-phosphate (S1P), but also some cholesterol-derived lipid mediators, as 24- and 25-hydroxycholesterols. The neurolipids can be autocrine or paracrine mediators participating in multiple physiological functions, such as cell proliferation, differentiation, cell migration, inflammation and apoptosis, but also in the development of different pathologies. Other neurotransmitter systems such as glutamatergic, γ-aminobutyric acid (GABA)ergic, dopaminergic or cholinergic system are modulating their synthesis and can be metabolized both enzymatically and non-enzymatically by oxidative degradation. Different G protein-coupled receptors (GPCR) for neurolipids have been identified and some GPCR orphan receptors could also be their target.

These neurolipid systems are very abundant, active and ubiquitously distributed in the different brain nucleus and cell types, including glial cells. Consequently, neurolipid systems are being analysed as powerful new therapeutic targets for the treatment of neurological diseases, including neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Huntington’s diseases, or multiple sclerosis. This Special Issue aims to collect the most advanced results in the promising neurolipid field applied to the development of new therapeutic approaches for neurodegenerative diseases.

Dr. Rafael Rodriguez-Puertas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Cannabinoid
  • Lysophospholipids
  • sphingosine 1 phosphate
  • lysophosphatidic acid
  • neurolipids
  • neurodegenerative diseases
  • Alzheimer’s disease
  • Parkinson’s disease
  • Hungtinton Chorea
  • Multiple sclerosis

Published Papers

This special issue is now open for submission.
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