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Special Issue "Modulation of Neuronal Excitability, Synaptic Transmission, and Plasticity in Health and Disease 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 31 July 2021.

Special Issue Editor

Prof. Dr. Claudio Grassi
E-Mail Website
Guest Editor
Department of Neuroscience, Medical School, Università Cattolica del Sacro Cuore, Rome, Italy
Interests: molecular and cellular neuroscience; synaptic transmission and plasticity; neuronal excitability; neural stem cells and adult neurogenesis
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Special Issue Information

Dear Colleagues,

Brain functions rely on information encoding and its transmission within neural networks. As such, ion channels allowing the generation of electrical signals and governing neuronal excitability play a critical role in all physiological processes of central and peripheral nervous systems. Neuronal signaling also requires synaptic function to transmit information and allow elaboration of more complex responses in neural circuitries of the human brain. Of note, synaptic plasticity, i.e., changes in the synaptic strength, is pivotal for high-order processes such as learning and memory. Dysregulation of these physiological mechanisms controlling information encoding and its transmission, relying on ion channels, neurotransmitter receptors, and intracellular pathways regulating their expression and/or function, causes pathophysiological processes underlying major neuropsychiatric disorders. Therefore, the understanding of molecular and cellular mechanisms controlling neuronal excitability and synaptic function is fundamental for the insight into brain function and dysfunction. The scope of the Special Issue is to summarize and enhance knowledge in this field.

Authors are invited to submit original research, communications, and review articles which address the progress and current standing of neuronal excitability and synaptic function.

Topics include but are not limited to:

  • Ion channel function and their modulation;
  • Channelopathies;
  • Mechanisms governing neurotransmitter release;
  • Neurotransmitter receptors and transporters;
  • Altered synaptic function in neurological diseases;
  • Mechanistic links between candidate genes and brain disorders characterized by altered neuronal excitability and/or synaptic function.

Prof. Dr. Claudio Grassi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Open AccessReview
Targeting Microglia-Synapse Interactions in Alzheimer’s Disease
Int. J. Mol. Sci. 2021, 22(5), 2342; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22052342 - 26 Feb 2021
Viewed by 654
In this review, we focus on the emerging roles of microglia in the brain, with particular attention to synaptic plasticity in health and disease. We present evidence that ramified microglia, classically believed to be “resting” (i.e., inactive), are instead strongly implicated in dynamic [...] Read more.
In this review, we focus on the emerging roles of microglia in the brain, with particular attention to synaptic plasticity in health and disease. We present evidence that ramified microglia, classically believed to be “resting” (i.e., inactive), are instead strongly implicated in dynamic and plastic processes. Indeed, there is an intimate relationship between microglia and neurons at synapses which modulates activity-dependent functional and structural plasticity through the release of cytokines and growth factors. These roles are indispensable to brain development and cognitive function. Therefore, approaches aimed at maintaining the ramified state of microglia might be critical to ensure normal synaptic plasticity and cognition. On the other hand, inflammatory signals associated with Alzheimer’s disease are able to modify the ramified morphology of microglia, thus leading to synapse loss and dysfunction, as well as cognitive impairment. In this context, we highlight microglial TREM2 and CSF1R as emerging targets for disease-modifying therapy in Alzheimer’s disease (AD) and other neurodegenerative disorders. Full article
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Review: Plasticity of neuronal intrinsic excitability in drug addiction
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