Special Issue "Chronic Pain: Spinal and Sovraspinal Neuroinflammation and Associated Negative Affective States"
Deadline for manuscript submissions: closed (31 March 2020).
Interests: pain; neuropsychopharmacology; neuroplasticity; neuroinflammation; endocannabinoids; glutamate
Special Issues and Collections in MDPI journals
Interests: depression; anxiety; pain; neuropsychopharmacology; endocannabinoids; serotonin
Interests: pain; neuroinflammation; glia; neuropharmacology
The scope of the Special Issue would be the evaluation of the reciprocal relationship existing between pain and negative affective states (i.e., the forebrain pain mechanisms) and, in particular, the highlighting of the most advanced knowledge that underlies some long-term functional changes in limbic structures (i.e., prefrontal cortex, amygdala, DR, and PAG). Moreover, a relevant aspect that should emerge from this Special Issue should be the highlighting of the cross talk between the classic neurotransmitters and neuromodulators (i.e., neuropeptides, glutamate, GABA, NO, and neurotrophic factors) with several other molecules of more recent identification (i.e., endocannabinoids, prostamides, etc.) that are able to work synergistically or in opposition in supporting the limbic system neural plasticity induced by chronic pain and the complex and unpredictable central sequelae. A further important topic to consider will be the emerging targets for reversing such abnormal activity in these neural circuitries may contribute to pain relief and to improve some negative affective states.
Prof. Dr. Sabatino Maione
Dr. Danilo De Gregorio
Dr. Francesca Guida
Manuscript Submission Information
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- chronic pain
- neural sensitization
- spinal cord
- cognitive impairment