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Special Issue "Chronic Pain: Spinal and Sovraspinal Neuroinflammation and Associated Negative Affective States-2nd Edition"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 30 June 2021.

Special Issue Editors

Prof. Dr. Sabatino Maione
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Guest Editor
Department of Experimental Medicine, Division of Pharmacology, University of Campania “L. Vanvitelli”, Naples 80138, Italy
Interests: pain; neuropsychopharmacology; neuroplasticity; neuroinflammation; endocannabinoids; glutamate
Special Issues and Collections in MDPI journals
Dr. Danilo De Gregorio
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Co-Guest Editor
Neurobiological Psychiatry Unit, Dept. Psychiatry, McGill University Montreal, Canada
Interests: depression; anxiety; pain; neuropsychopharmacology; endocannabinoids; serotonin
Special Issues and Collections in MDPI journals
Dr. Francesca Guida
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Co-Guest Editor
University of Campania “L. Vanvitelli”, Department of Experimental Medicine, Naples, Italy
Interests: pain; neuroinflammation; glia; neuropharmacology
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

The scope of the Special Issue would be the evaluation of the reciprocal relationship existing between pain and negative affective states (i.e., the forebrain pain mechanisms) and, in particular, the highlighting of the most advanced knowledge that underlies some long-term functional changes in limbic structures (i.e., prefrontal cortex, amygdala, DR, and PAG). Moreover, a relevant aspect that should emerge from this Special Issue should be the highlighting of the cross talk between the classic neurotransmitters and neuromodulators (i.e., neuropeptides, glutamate, GABA, NO, and neurotrophic factors) with several other molecules of more recent identification (i.e., endocannabinoids, prostamides, etc.) that are able to work synergistically or in opposition in supporting the limbic system neural plasticity induced by chronic pain and the complex and unpredictable central sequelae. A further important topic to consider will be the emerging targets for reversing such abnormal activity in these neural circuitries may contribute to pain relief and to improve some negative affective states.

Prof. Dr. Sabatino Maione
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers

This special issue is now open for submission.
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