Dear Colleagues,

Despite nearly one hundred years of translational research, we still lack clear-cut answers to the crucial question of the pathophysiology of most neuropsychiatric disorders and the molecular/cellular mechanisms of their treatment. Under the umbrella of neuropsychiatric disorders, we count disorders of affect, cognition, and behaviour that arise from aberrant cerebral function, or from indirect molecular effects of extracerebral disease.  Included in this term are addictions, psychoses, degenerative diseases, and eating, mood, neurotic, and sleep disorders. Without their biological etio-pathological rationale, drug development has stagnated. In this Special Issue, we wish to publish papers dealing with biological approaches to understanding neuropsychiatric diseases for the purpose of accelerating the discovery and development of better treatments. We welcome reports of preclinical datasets from worldwide disease cohorts to which innovative technologies have been applied to define quantifiable biological parameters for the different symptoms of these disorders. We also welcome papers that describe studies identifying molecular targets for novel drug development and predictive or molecular studies in animal models. Overall, we strive to suggest routes to new translation-evidence-based treatments in the fields of psychiatry and neurology.

Prof. Dr. Galila Agam
Guest Editor

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• pathophysiology of neuropsychiatric disorders
• molecular treatment mechanisms
• molecular studies in animal models
• molecular targets for novel drug development