Special Issue "Neuroregeneration and Brain Repair after Stroke"
Deadline for manuscript submissions: closed (28 February 2021).
Stroke is the second leading cause of death and a major cause of disability worldwide. Although acute stroke therapies such as recombinant human tissue-type plasminogen activator and endovascular thrombectomy effectively reduce mortality and alleviate neurological deficits, poor functional outcomes in stroke survivors are still present. In the chronic stage of stroke, only rehabilitation is established as a conventional strategy for functional recovery. Thus, therapies to improve functional recovery are urgently needed.
During recovery of stroke, many molecular cascades that produce inflammatory processes, spontaneous brain repair, and neuro-regeneration. Circulating endothelial progenitor cells as well as cerebral endothelial cells in survived blood vessels are involved in the mechanisms of angiogenesis. Production of neural stem and progenitor cells is promoted, and these cells are migrated to stroke lesions. Additionally, axonal outgrowth and oligodendrogenesis are facilitated in the peri-infarct gray and white matter, and regenerated and myelinated fibers contribute to repairing injured brains. On the other hand, astrocytic glial scar formation suppresses axonal regeneration with the production of inhibitory molecules.
For this Special Issue, we are seeking novel molecular mechanisms that facilitate neurogenesis and brain repair after stroke in various experimental systems. I look forward to your contributions.
Assoc. Prof. Yuji Ueno
Manuscript Submission Information
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- axonal outgrowth
- glial scar
- regenerative medicine
- restorative therapy
- stem cells