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Special Issue "Molecular Mechanisms and Treatments of Dependence and Neurotoxicity of Amphetamine-Type Stimulants"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 30 June 2021.

Special Issue Editor

Prof. Dr. Anna Moszczynska
E-Mail Website
Guest Editor
Department of Pharmaceutical Sciences/College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA
Interests: methamphetamine use disorder; methamphetamine neurotoxicity; the role of protein-ubiquitin ligase parkin in methamphetamine use disorder and neurotoxicity; neurodegeneration and neuroprotection

Special Issue Information

Dear Colleagues,

Amphetamine-type stimulants (ATSs) such as methamphetamine and 3,4-methylene-dioxymethamphetamine (MDMA, Ecstasy) are highly addictive drugs with neurotoxic properties. The use of ATSs is a global and growing phenomenon, and in recent years there has been a pronounced increase in the production and use of ATSs worldwide. Preclinical studies have demonstrated that, in addition to having the potential for abuse, ATS drugs have a potential to elicit neurotoxic effects, particularly at high doses. There are no FDA-approved pharmacotherapies to treat ATS dependence, and there are no appropriate therapeutic strategies to manage the neurological and neuropsychological problems associated with ATS abuse. This Special Issue will review current knowledge on molecular mechanisms underlying the dependence and neurotoxicity of methamphetamine, MDMA, and other ATSs, as well as developing strategies to treat ATS dependence and resultant neurotoxicity. The emphasis will be placed on methamphetamine, as its abuse in the United States has been increasing, together with the deaths from methamphetamine overdose. Consequently, the development of effective pharmacotherapy for methamphetamine dependence and the neurotoxic effects of this drug is a high priority.

Prof. Dr. Anna Moszczynska
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Amphetamine-type stimulants
  • Amphetamine-type stimulant dependence
  • Amphetamine-type-stimulant neurotoxicity
  • Amphetamine-type-stimulant-induced oxidative damage, degeneration, and inflammation
  • Therapies for amphetamine-type-stimulant dependence
  • Methamphetamine use disorder
  • Methamphetamine toxicities
  • Emerging drug targets for pharmacotherapies to treat amphetamine-type-stimulant dependence and neurotoxicity

Published Papers

This special issue is now open for submission.
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