Special Issue "The Diversity of Mammalian Nod-Like Receptor Functions"
Deadline for manuscript submissions: closed (31 December 2020).
Interests: NLR proteins; NLRP3 inflammasome; NLRC5, macrophage subtypes; innate immunity; cell signaling; gene expression
Interests: NLR proteins; NOD1, NOD2, NLRC5, NLRP10; host–pathogen interactions; immunity; inflammation
Nod-like receptors (NLRs) form a family of intracellular pattern recognition receptors that were first described about 20 years ago. They show high domain similarity to the intracellular R proteins, which are responsible for disease resistance in plants, and to membrane-bound Toll-like receptors (TLRs) in animals and humans. The high homology to other well-described pattern recognition receptors quickly attracted attention. Intensive study of some NLR members revealed that NLRs sense a variety of microbial or stress molecules, can from inflammasomes, act as high-molecular weight signaling hubs, or regulate signal transduction pathways and gene expression. However, some NLRs also contribute to gametogenesis, fertility, embryonal development, and metabolism. Medical interest arose, with studies showing associations of polymorphisms in certain NLR-encoding genes with autoinflammatory and autoimmune diseases, hypersensitivity reactions, and cancer.
The NLR family contains more than 20 members in most mammals. However, research mainly focused on a handful of these proteins, the most prominent examples being NOD1, NOD2, and NLRP3. Beside these well-characterized NLRs, other members of the NLR family have received less attention, and the function of several human NLRs still remains elusive.
This Special Issue, “The Diversity of Mammalian Nod-like Receptor Functions”, invites original research and review articles that address aspects of NLR functions. We encourage submissions of work on non-inflammasome forming NLRs and on understudied inflammasomes and NLR members in human and other mammalian species, amongst others. This Special Issue aims to provide a timely overview of the knowns and unknows of NLR biology.
Dr. Szilvia Benko
Prof. Thomas A. Kufer
Manuscript Submission Information
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- cell death
- innate immunity