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Special Issue "Nonapeptide Hormones"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 20 December 2021.

Special Issue Editors

Prof. Richard Ebstein
E-Mail Website
Guest Editor
Department of Psychology, National University of Singapore, Singapore
Interests: vasopressin; oxytocin; neuroeconomics; the genetics of social behavior and normal personality; autism; ADHD; eating disorders; substance abuse
Dr. Serenella Tolomeo
E-Mail Website
Guest Editor
Department of Psychology, National University of Singapore, Singapore
Interests: Neuroscience, Neuroimaging, Psychiatry, Genetics

Special Issue Information

Dear Colleagues,

Two nonapeptide hormones, arginine vasopressin (AVP) and oxytocin (OXT), with a similar evolutionary history spanning half a billion years, have emerged as focuses of considerable interest in social neuroscience, as paramount human social or affiliative hormones. These nonapeptides, and their associated neural systems, are salient mediators of both normal and dysfunctional human behavior. Of some interest is their possible role in autism, a human disorder characterized by shortfalls in communication and social skills. AVP and OXT are important in cementing human bonding starting in infancy and continuing across adulthood. Notably, OXT (AVP neural pathways including the receptors for oxytocin (OXTR) and arginine vasopressin (AVPR1a and 1b)), CD38 (an ADP- ribosyl cyclase that mediates brain OXT release), and oxytocinase (LNPEP) (the enzyme that metabolizes OXT and AVP) constitute the broad AVP–OXT regulatory landscape. This Special Issue seeks papers focusing on the role of nonapeptides in human social relations, both normative and dysfunctional, which will shed light on how humans, by cooperating, trusting, and communicating, have become so successful and thrive across the planet. Investigations covering such diverse experimental domains as evolution, behavioral economics, molecular genetics, imaging genomics, pharmacology, and endocrinology are invited.

Prof. Richard Ebstein
Dr. Serenella Tolomeo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

Article
Oxytocin Signaling Acts as a Marker for Environmental Stressors in Zebrafish
Int. J. Mol. Sci. 2021, 22(14), 7459; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147459 - 12 Jul 2021
Viewed by 511
Abstract
The oxytocin system plays a role in stress responses and behavior modulation. However, the effects of oxytocin signaling on stress adaptation remain unclear. Here, we demonstrated the roles of oxytocin signaling as a biomarker under stress conditions in the peripheral tissues (the gills) [...] Read more.
The oxytocin system plays a role in stress responses and behavior modulation. However, the effects of oxytocin signaling on stress adaptation remain unclear. Here, we demonstrated the roles of oxytocin signaling as a biomarker under stress conditions in the peripheral tissues (the gills) and central nervous system (the brain). All the environmental stressors downregulated the expression of oxytocin receptors in the gills, and the alteration of the expression of oxytocin receptors was also found in the brain after the acidic (AC) and high-ammonia (HA) treatments. The number of oxytocin neurons was increased after double-deionized (DI) treatment. By transgenic line, Tg(oxtl:EGFP), we also investigated the projections of oxytocin neurons and found oxytocin axon innervations in various nuclei that might regulate the anxiety levels and aggressiveness of adult zebrafish under different environmental stresses. The oxytocin system integrates physiological responses and behavioral outcomes to ensure environmental adaptation in adult zebrafish. Our study provides insight into oxytocin signaling as a stress indicator upon environmental stressors. Full article
(This article belongs to the Special Issue Nonapeptide Hormones)
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