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Special Issue "Tackling New and Reemerging Infectious Diseases through the Development of Novel Anti-infectives"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 August 2021.

Special Issue Editors

Prof. Dr. Clemente Capasso
E-Mail Website
Guest Editor
Institute of Bioscience and Bioresources (IBBR), National Research Council, Via Pietro Castellino 111, 80131 Napoli, Italy
Interests: protein biochemistry; recombinant protein; heterologous expression; carbonic anhydrase; enzyme and protein purification; enzyme characterization; enzyme thermostability; cold-adapted enzymes
Special Issues and Collections in MDPI journals
Prof. Dr. Claudiu T. Supuran
grade E-Mail Website
Guest Editor
Neurofarba Department, Section of Farmaceutical and Neutraceutical Sciences, University of Florence, Sesto Fiorentino (Florence) 50019, Italy
Interests: drug design; metalloenzymes; carbonic anhydrases, anticancer agents; antiinfectives; sulfonamides; coumarins
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

The multiple challenges to the endemic, epidemic, and pandemic of infectious diseases call for a worldwide, systematic approach to quickening the efforts to discover pharmacological agents against new and reemerging infectious diseases. For example, no specific drugs are currently available to treat COVID-19, resulting in many associated morbidities and deaths frequently recorded, mostly among elderly patients affected by chronic pathologies. Although vaccines for Covid-19 are available, the urgency to identify effective drugs (i.e., antivirals) remains as, on a large scale, immunization reaches its effectiveness outside the time frame allowed to handle a potentially catastrophic pandemic. Moreover, antiviral drugs' association with vaccines represents an ideal pharmacological strategy to control the viral spread. Contagious diseases caused by viruses and resistant bacteria represent a growing global health risk across public health concerns mainly because infections are believed to occur with increasing frequency and importance, with expansions in global population, travel, climate change, and geopolitical threats. The characterization of pathogen biology, pathogenesis, and host-response genomic pathways across multiple infectious agents, offers the possibility to find new targets of interventions (e.g., crucial enzymes), which serve as broad-spectrum drug targets. They can be modulated by novel or repurposed therapeutic modalities and will similarly impact numerous pathogens. Of course, the decline in the number of new drugs being approved, combined with an economically unsustainable rise in costs, representing the pharmaceutical industry's paradox in the pharmaceutical industry, should be solved.

Prof. Dr. Clemente Capasso
Prof. Dr. Claudiu T. Supuran
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antivirals
  • antibacterials
  • virus
  • CoViD-19
  • pathogenic bacteria
  • antibiotic resistance
  • antifungals
  • anthelmintics
  • antimalarials
  • antiprotozoals

Published Papers (2 papers)

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Review

Open AccessReview
Candida auris: A Quick Review on Identification, Current Treatments, and Challenges
Int. J. Mol. Sci. 2021, 22(9), 4470; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094470 - 25 Apr 2021
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Abstract
Candida auris is a novel and major fungal pathogen that has triggered several outbreaks in the last decade. The few drugs available to treat fungal diseases, the fact that this yeast has a high rate of multidrug resistance and the occurrence of misleading [...] Read more.
Candida auris is a novel and major fungal pathogen that has triggered several outbreaks in the last decade. The few drugs available to treat fungal diseases, the fact that this yeast has a high rate of multidrug resistance and the occurrence of misleading identifications, and the ability of forming biofilms (naturally more resistant to drugs) has made treatments of C. auris infections highly difficult. This review intends to quickly illustrate the main issues in C. auris identification, available treatments and the associated mechanisms of resistance, and the novel and alternative treatment and drugs (natural and synthetic) that have been recently reported. Full article
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Open AccessReview
A Highlight on the Inhibition of Fungal Carbonic Anhydrases as Drug Targets for the Antifungal Armamentarium
Int. J. Mol. Sci. 2021, 22(9), 4324; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094324 - 21 Apr 2021
Viewed by 238
Abstract
Carbon dioxide (CO2), a vital molecule of the carbon cycle, is a critical component in living organisms’ metabolism, performing functions that lead to the building of compounds fundamental for the life cycle. In all living organisms, the CO2/bicarbonate (HCO [...] Read more.
Carbon dioxide (CO2), a vital molecule of the carbon cycle, is a critical component in living organisms’ metabolism, performing functions that lead to the building of compounds fundamental for the life cycle. In all living organisms, the CO2/bicarbonate (HCO3) balancing is governed by a superfamily of enzymes, known as carbonic anhydrases (CAs, EC 4.2.1.1). CAs catalyze the pivotal physiological reaction, consisting of the reversible hydration of the CO2 to HCO3 and protons. Opportunistic and pathogenic fungi can sense the environmental CO2 levels, which influence their virulence or environmental subsistence traits. The fungal CO2-sensing is directly stimulated by HCO3 produced in a CA-dependent manner, which directly activates adenylyl cyclase (AC) involved in the fungal spore formation. The interference with CA activity may impair fungal growth and virulence, making this approach interesting for designing antifungal drugs with a novel mechanism of action: the inhibition of CAs linked to the CO2/HCO3/pH chemosensing and signaling. This review reports that sulfonamides and their bioisosteres as well as inorganic anions can inhibit in vitro the β- and α-CAs from the fungi, suggesting how CAs may be considered as a novel “pathogen protein” target of many opportunistic, pathogenic fungi. Full article
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