Neurobiology and Molecular Research of Nutraceuticals in Neurodegenerative Disorders
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (29 February 2020) | Viewed by 21142
Special Issue Editor
Interests: neuroanatomy; neuroscience; neurodegeneration; methamphetamine; autophagy; movement disorders; substances of abuse; morphology; ultrastructure
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The term “nutraceuticals” refers to products of natural origin, which are used for the prevention or treatment of a variety of diseases. Owing to their beneficial effects, nutraceuticals such as polyphenols have gained increasing importance in the context of neurodegenerative disorders. The advantage of herbal products such as curcumin, resveratrol, ashwagandha, and green tea stems from their naturally mild but multiple potentialities to target those molecular pathways, which operate during neurotoxicity and neurodegeneration. These encompass oxidative stress, mitochondrial and cell-clearing systems dysfunctions, protein aggregation, and prion-like spreading, as well as neuroinflammation. Thus, nutraceuticals are promising candidates for preventing and slowing down progression of neuronal damage in a plethora of brain disorders, such as Parkinson’s, Alzheimer’s, and Huntington’s diseases, Multiple sclerosis, and Amyotrophic lateral sclerosis. Nonetheless, further studies in different experimental settings are mandatory to elucidate the neurobiological and molecular mechanisms of action of single and combined nutraceuticals, as well as to develop strategies aimed at potentiating their bioavailability in human cells.
In this Special Issue, we welcome experts to contribute research papers and critical reviews on neurobiology and molecular research of nutraceuticals in neurodegenerative disorders.
Prof. Dr. Francesco Fornai
Guest Editor
Manuscript Submission Information
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Keywords
- polyphenols
- free radicals
- mitochondria
- neuroinflammation
- neurotoxicity
- neurodegenerative disorders
- autophagy
- proteasome
- prionoids
- proteinopathies
