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Special Issue "Research on Nutrigenetics and Nutrigenomics"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editors

Dr. Nicoleta Andreescu
E-Mail Website
Guest Editor
Centre of Genomic Medicine, Genetics Discipline, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania
Interests: nutrigenetics; pharmacogenetics; personalized medicine; medical genetics; molecular genetics
Prof. Dr. Atanas G. Atanasov
E-Mail Website
Guest Editor
Department of Molecular Biology, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, Magdalenka, Poland
Interests: molecular medicine; nutrigenomics; natural products; digital health; open innovation; molecular pharmacology; biotechnology
Dr. Barbara Benassi
E-Mail Website
Guest Editor
ENEA, Division of Health Protection Technologies, Via Anguillarese 301, 00123 Rome, Italy
Interests: diet and epigenetics; dietary effects on DNA methylation; histone remodeling and mRNA stability; biochemistry

Special Issue Information

Dear Colleagues,

Nutrigenomics has been called a “post-genome” field of research because it could only develop in a meaningful way after the completion of the sequencing of the human genome. Nutritional genomics, or nutrigenomics, attempts to study the genome-wide influences of nutrition and identify the genes that influence the risk of diet-related diseases on a genome-wide scale, and to understand the mechanisms that underlie these genetic predispositions. While traditional nutrition research concentrated on nutrient deficiencies and impairment of health, it nowadays focuses on improving health through diet.

As a new science, nutrigenomics brings along new terminology, novel experimental techniques, and a fundamentally new approach to nutrition research, such as high-throughput technologies that enable the global study of gene expression in a cell or organism.

The purpose of this Special Issue is to provide new insights on the use of nutrigenomics for improving health through diet.

Dr. Nicoleta Andreescu
Prof. Dr. Atanas G. Atanasov
Dr. Barbara Benassi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutrigenetics fatty liver
  • personalized medicine
  • genetic variants
  • nutriepigenetics
  • fertility
  • foodomics

Published Papers (1 paper)

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Research

Article
Alteration of the Early Development Environment by Maternal Diet and the Occurrence of Autistic-like Phenotypes in Rat Offspring
Int. J. Mol. Sci. 2021, 22(18), 9662; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22189662 - 07 Sep 2021
Cited by 1 | Viewed by 467
Abstract
Epidemiological and preclinical studies suggest that maternal obesity increases the risk of autism spectrum disorder (ASD) in offspring. Here, we assessed the effects of exposure to modified maternal diets limited to pregnancy and lactation on brain development and behavior in rat offspring of [...] Read more.
Epidemiological and preclinical studies suggest that maternal obesity increases the risk of autism spectrum disorder (ASD) in offspring. Here, we assessed the effects of exposure to modified maternal diets limited to pregnancy and lactation on brain development and behavior in rat offspring of both sexes. Among the studied diets, a maternal high-fat diet (HFD) disturbed the expression of ASD-related genes (Cacna1d, Nlgn3, and Shank1) and proteins (SHANK1 and TAOK2) in the prefrontal cortex of male offspring during adolescence. In addition, a maternal high-fat diet induced epigenetic changes by increasing cortical global DNA methylation and the expression of miR-423 and miR-494. As well as the molecular changes, behavioral studies have shown male-specific disturbances in social interaction and an increase in repetitive behavior during adolescence. Most of the observed changes disappeared in adulthood. In conclusion, we demonstrated the contribution of a maternal HFD to the predisposition to an ASD-like phenotype in male adolescent offspring, while a protective effect occurred in females. Full article
(This article belongs to the Special Issue Research on Nutrigenetics and Nutrigenomics)
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