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Nutrition Genomics 2.0
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Nutrition Genomics 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (28 February 2021) | Viewed by 10507

Special Issue Editors

Prof. Dr. Jesús Osada

E-Mail Website
Guest Editor
Departamento de Bioquímica y Biología Molecular y Celular, Facultad de Veterinaria, Universidad de Zaragoza, Zaragoza, Spain
Interests: transcriptomics; diet; medicinal plant
Special Issues, Collections and Topics in MDPI journals
Dr. Adela Ramírez-Torres

E-Mail Website
Guest Editor
Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The scientific interest in characterizing the whole genome response to nutrients is becoming of paramount interest considering that nutrition is one of the crucial events in cell and organism lives. With the recent incorporation of microarrays and whole genome, a sequence is technically feasible. Gathering all the research carried out in the field represents an endless process, and in this way, this issue offers a unique opportunity to those researchers dealing with these aspects.

This Special Issue will cover a selection of recent research topics and current review articles in the field of diets and high-throughput gene expression. Experimental papers, up-to-date review articles, and commentaries are all welcome. Contributions to this Special Issue may cover all aspects of diets and high-throughput gene expression, including epigenomics modifications in any tissue. When complex diets are used, they should be perfectly characterized. Both microarrays and RNA seq methods are welcome. By the time of submission, raw data will have been deposited at public repositories. Confirmation of data with an independent approach for RNA or at protein level, when analyzing mRNA, will certainly be encouraged. When using qPCR, adherence to MIQE guidelines will be required.

Prof. Dr. Jesús Osada
Dr. Adela Ramírez-Torres
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Diet
  • Nutrient
  • Microarrays
  • DNA sequencing
  • Epigenomics
  • Transcriptomics

Related Special Issue

Published Papers (2 papers)

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Editorial

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3 pages, 200 KiB  
Editorial
Nutrition Genomics
by Jesús Osada
Int. J. Mol. Sci. 2023, 24(7), 6490; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms24076490 - 30 Mar 2023
Viewed by 1105
Abstract
This Special Issue is devoted to nutrition genomics, which is the characterization of the whole genome response to nutrients, in an effort to gather all the available pertinent information and to establish the foundation for a future encyclopedia of genomic responses driven by [...] Read more.
This Special Issue is devoted to nutrition genomics, which is the characterization of the whole genome response to nutrients, in an effort to gather all the available pertinent information and to establish the foundation for a future encyclopedia of genomic responses driven by diets or nutrients [...] Full article
(This article belongs to the Special Issue Nutrition Genomics 2.0)

Research

Jump to: Editorial

18 pages, 2032 KiB  
Article
Bovine Milk-Derived Exosomes as a Drug Delivery Vehicle for miRNA-Based Therapy
by Lorena del Pozo-Acebo, M-C López de las Hazas, Joao Tomé-Carneiro, Paula Gil-Cabrerizo, Rodrigo San-Cristobal, Rebeca Busto, Almudena García-Ruiz and Alberto Dávalos
Int. J. Mol. Sci. 2021, 22(3), 1105; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22031105 - 22 Jan 2021
Cited by 88 | Viewed by 8876
Abstract
MicroRNAs (miRNAs) are small non-coding RNAs with a known role as mediators of gene expression in crucial biological processes, which converts them into high potential contenders in the ongoing search for effective therapeutic strategies. However, extracellular RNAs are unstable and rapidly degraded, reducing [...] Read more.
MicroRNAs (miRNAs) are small non-coding RNAs with a known role as mediators of gene expression in crucial biological processes, which converts them into high potential contenders in the ongoing search for effective therapeutic strategies. However, extracellular RNAs are unstable and rapidly degraded, reducing the possibility of successfully exerting a biological function in distant target cells. Strategies aimed at enhancing the therapeutic potential of miRNAs include the development of efficient, tissue-specific and nonimmunogenic delivery methods. Since miRNAs were discovered to be naturally transported within exosomes, a type of extracellular vesicle that confers protection against RNase degradation and increases miRNA stability have been proposed as ideal delivery vehicles for miRNA-based therapy. Although research in this field has grown rapidly in the last few years, a standard, reproducible and cost-effective protocol for exosome isolation and extracellular RNA delivery is lacking. We aimed to evaluate the use of milk-derived extracellular vesicles as vehicles for extracellular RNA drug delivery. With this purpose, exosomes were isolated from raw bovine milk, combining ultracentrifugation and size exclusion chromatography (SEC) methodology. Isolated exosomes were then loaded with exogenous hsa-miR148a-3p, a highly expressed miRNA in milk exosomes. The suitability of exosomes as delivery vehicles for extracellular RNAs was tested by evaluating the absorption of miR-148a-3p in hepatic (HepG2) and intestinal (Caco-2) cell lines. The potential exertion of a biological effect by miR-148a-3p was assessed by gene expression analysis, using microarrays. Results support that bovine milk is a cost-effective source of exosomes which can be used as nanocarriers of functional miRNAs with a potential use in RNA-based therapy. In addition, we show here that a combination of ultracentrifugation and SEC technics improve exosome enrichment, purity, and integrity for subsequent use. Full article
(This article belongs to the Special Issue Nutrition Genomics 2.0)
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