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Special Issue "Nutritional Biochemistry"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 31 January 2022.

Special Issue Editor

Prof. Dr. Shih-Min Hsia
E-Mail Website
Guest Editor
School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan
Interests: effect of natural products on female disorders such as PCOS; leiomyoma; endometriosis; dysmenorrhea; breast cancer; endometrial cancer and ovary cancer
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Nutritional biochemistry involves a wide range of fields, including biology, chemistry, cell function and metabolism, preclinical nutrition, macronutrients and energy, and nutrigenomics. Previous research has explored the operation of nutritional biochemistry through different methods, confirming the mechanism and related pathways regulated by nutritional biochemistry at the cellular level, simulating the intake required by the human body through animal experiments, applying it to humans in clinical nutrition trials, and finally establishing the optimal balance with diet and nutritional requirements. A large number of studies on nutritional biochemistry have focused not only on uncovering the relationship between diet and disease but also on revealing the importance of nutritional intake in the development of cancer.

The scope of nutritional biochemical research is wide, and there are still many molecular mechanisms that need to be elucidated. To provide more advantageous evidence, this Special Issue is expected to recruit research on the improvement of diseases or cancer with nutritional nutraceuticals or active compounds and to seek to develop strategies to reduce the side effects of clinical drugs.

Prof. Dr. Shih-Min Hsia
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biology
  • chemistry
  • cell function and metabolism
  • preclinical nutrition
  • macronutrients and energy
  • nutrigenomics

Published Papers (1 paper)

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Research

Article
Hydroxygenkwanin Increases the Sensitivity of Liver Cancer Cells to Chemotherapy by Inhibiting DNA Damage Response in Mouse Xenograft Models
Int. J. Mol. Sci. 2021, 22(18), 9766; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22189766 - 09 Sep 2021
Viewed by 587
Abstract
Molecules involved in DNA damage response (DDR) are often overexpressed in cancer cells, resulting in poor responses to chemotherapy and radiotherapy. Although treatment efficacy can be improved with the concomitant use of DNA repair inhibitors, the accompanying side effects can compromise the quality [...] Read more.
Molecules involved in DNA damage response (DDR) are often overexpressed in cancer cells, resulting in poor responses to chemotherapy and radiotherapy. Although treatment efficacy can be improved with the concomitant use of DNA repair inhibitors, the accompanying side effects can compromise the quality of life of patients. Therefore, in this study, we identified a natural compound that could inhibit DDR, using the single-strand annealing yeast-cell analysis system, and explored its mechanisms of action and potential as a chemotherapy adjuvant in hepatocellular carcinoma (HCC) cell lines using comet assay, flow cytometry, Western blotting, immunofluorescence staining, and functional analyses. We developed a mouse model to verify the in vitro findings. We found that hydroxygenkwanin (HGK) inhibited the expression of RAD51 and progression of homologous recombination, thereby suppressing the ability of the HCC cell lines to repair DNA damage and enhancing their sensitivity to doxorubicin. HGK inhibited the phosphorylation of DNA damage checkpoint proteins, leading to apoptosis in the HCC cell lines. In the mouse xenograft model, HGK enhanced the sensitivity of liver cancer cells to doxorubicin without any physiological toxicity. Thus, HGK can inhibit DDR in liver cancer cells and mouse models, making it suitable for use as a chemotherapy adjuvant. Full article
(This article belongs to the Special Issue Nutritional Biochemistry)
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