Journal Browser

Journal Browser

Special Issue "Dysregulation of Human Molecular and Metabolic Mechanisms Resulting in Oxidative Stress and Damage Generation in the Space Environment"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 July 2021.

Special Issue Editors

Prof. Dr. Melpo Christofidou-Solomidou
Guest Editor
Division of Pulmonary, Allergy, and Critical Care Medicine and the Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
Interests: oxidative stress; antioxidants; botanicals; radiation toxicity; lung inflammation; lung fibrosis; space radiation; radiotherapy
Special Issues and Collections in MDPI journals
Dr. Thomas J. Goodwin
Website1 Website2
Guest Editor
Sovaris Aerospace, Research Innovation, Infectious Disease Research Center Colorado State University; The National Aeronautics and Space Administration (NASA retired) Johnson Space Center, Houston, TX 77058, USA
Interests: ageing; oxidative stress and damage; antioxidants; radiation toxicity; inflammation; genomics; proteomics; metabolomics
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues:

The phenomenon of oxidative stress and damage (OSaD) is recognized as an important common denominator in human physiological function and disease occurrence, on Earth and in space, signifying the vital nature of the topic. Advanced and evolving “multi-omics” technologies permit the analyses of essential molecular and metabolic processes in the medical arena, facilitating planning for deep space exploration missions with the intent to discover new habitats and commercial markets for humankind. In the past, the National Aeronautics and Space Administration (NASA) has spearheaded this effort and research into the identification of risks to crew members associated with such lengthy missions. Now, commercial and defense efforts are pioneering promising applications of the space environment in low Earth orbit (LEO). Investigators across the US, Europe, and Asia have identified oxidative damage as a significant risk to organ systems that could pose a threat to the health of astronauts and the success of a variety of missions. This Special Issue of IJMS is dedicated to providing a comprehensive overview of the identified elemental risks and pivotal theme of OSaD impact in major organ systems when exposed to space-relevant conditions, such as cosmic/galactic radiation, solar particle events, hypogravity, hyperoxia, and hypoxia or a combination of these stressors.

Prof. Dr. Melpo Christofidou-Solomidou
Dr. Thomas J. Goodwin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • OSaD
  • Galactic cosmic radiation (GCR)
  • Deep space exploration
  • Low earth orbit commercialization
  • Health risk mitigation
  • Tissue toxicity

Published Papers

This special issue is now open for submission.
Back to TopTop