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Special Issue "Oligodendrocyte Lineage Cells"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editor

Dr. Takakuni Maki
E-Mail Website
Guest Editor
Department of Neurology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawaharacho, Sakyoku, Kyoto 606-8507, Japan
Interests: oligodendrocytes; oligodendrocyte precursor cells; neurovascular unit; cell-cell interaction; stroke; vascular dementia; Alzheimer’s disease; cerebral amyloid angiopathy; multiple system atrophy

Special Issue Information

Dear Colleagues,

Recent research advances are gradually revealing that oligodendrocyte lineage cells have more diverse and crucial roles in the brain than previously recognized, actively participating in the control of brain homeostasis. Oligodendrocyte precursor cells (OPCs) are uniformly distributed in both gray and white matter, displaying robust proliferative and migratory potential, with constant surveillance capacity in the adult brain. In addition to a well-known role of reservoir for mature oligodendrocytes (OLGs) which form myelin sheaths and promote saltatory nerve conduction, OPCs have been shown to regulate the neurovascular unit (i.e., neuronal, glial, vascular, and immune systems) in a direct and reciprocal fashion. They exhibit wide heterogeneity and may have dual “detrimental” and “beneficial” effects in response to various types of injuries in different locations. However, the multifaceted roles of oligodendrocyte lineage cells under normal and pathological conditions still remain to be fully elucidated. Hence, the scope of the Special Issue is to summarize and enlarge the knowledge regarding oligodendrocyte lineage cells in health and disease. Therefore, authors are invited to submit original research and review articles which address the progress and current understanding of oligodendrocyte lineage cells.

Topics include, but are not limited to:

  • Diverse aspects of interactions between oligodendrocyte lineage cells and other cell types
  • Unrecognized functions of oligodendrocyte lineage cells in developing and adult brains
  • Multifaceted roles of olidodendrocyte lineage cells in various CNS diseases

Dr. Takakuni Maki
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Oligodendrocytes
  • Oligodendrocyte lineage cells
  • Oligodendrocyte precursor cells
  • Glia
  • Neurovascular unit
  • Cell–cell interaction

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Amyloidogenic and non-amyloidgenic pathway of amyloid precursor protein processing in oligodendrocyte lineage cells
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