Special Issue "Omics Strategies in Male Reproduction"
Deadline for manuscript submissions: 30 April 2022.
Interests: male infertility; spermatogenesis; sperm physiology and pathology; environmental factors; semen quality; seminal biomarkers; male genital tract inflammation/infection; microbiota of male genital tract; oxidative stress; sperm mitochondria; sperm chromatin integrity; sperm epigenetics; seminal proteom; seminal metabolom
Interests: seminal microbiota composition in health and disease; male infertility metagenomic research; high throughput techniques and omics data in male infertility studies
Male infertility has become a social and civilization disease, and started to be a serious challenge for public health. Due to limited predictive value of standard semen analysis in assessing the ability of the sperm to fertilize the oocyte, highly specialized scientific and diagnostic tools are needed to look for new non-invasive seminal biomarkers of male infertility, both in natural and assisted reproduction. Molecular research in sperm biology and male infertility is a very dynamic field of science. Omics-based studies using high-throughput technologies offer great potential for understanding the regulatory mechanisms that drive gene and protein expression during sperm development, detecting gene-environment or host-pathogen interactions underlying normal and pathological spermatogenesis. This research strategy is crucial to gain enough knowledge to envisage future diagnostic and therapeutic procedures to improve human reproductive health.
The idea of the Special Issue is to advance the research on male infertility and the molecular background of spermatogenesis. Both original manuscripts and reviews discussing the genome, transcriptome, epigenome, proteome and metabolome data related to male factor fertility/infertility in humans and animal models are very welcome.
Prof. Dr. Monika Frączek
Dr. Marzena Skrzypczak-Zielińska
Manuscript Submission Information
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- male infertility
- normal and pathological spermatogenesis
- seminal biomarkers
- sperm chromatin
- 16S rRNA gene sequencing
- next generation sequencing
- cell in vitro studies
- animal model studies