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Special Issue "Molecular Treatment in Optic Neuropathies"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 31 August 2021.

Special Issue Editor

Dr. Cécile Delettre
E-Mail Website
Guest Editor
Université Montpellier Sud de France, Institut of Neurosciences of Montpellier, INSERM U1051, 80 rue Augustin Fliche, Hôpital Saint Eloi, 34090 Montpellier, France
Interests: optic neuropathy; retina; mitochondria; optic nerve; link between endoplasmic reticulum and mitochondria; genetics of optic neuropathies

Special Issue Information

Dear Colleagues,

We are pleased to announce that we are soliciting proposals for contributions to the upcoming Special Issue “Molecular Treatment in Optic Neuropathies”.

Inherited Optic Neuropathies (IONs) are diseases that cause blindness due to the degeneration of the Retinal Ganglion Cells (RGCs), the neurons that transduce the visual information from the retina to the brain via the optic nerve. IONs are linked to genes coding proteins with a major role in the mitochondrial function. These proteins are ubiquitous; therefore, the preferential degeneration of the RGCs remains a mystery. IONs can be isolated, affecting exclusively the RGCs, or syndromic, with a clinical table typical of mitochondrial diseases with classically a loss of vision, deafness, and encephalomyopathy, which can be associated with neuromuscular or endocrinal troubles. Leber hereditary optic neuropathy (LHON) and autosomal dominant optic atrophy (DOA) are the two most common forms of ION. Major advances in our understanding of the mechanisms supporting RGC loss in these disorders are paving the way for novel forms of treatment aimed at stopping or reversing visual loss at different stages of the disease process. This Special Issue aims to publish the latest research on neuroprotective, neuroregenerative, and gene therapeutic strategies for these mitochondrial optic nerve disorders.

Dr. Cécile Delettre
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • mitochondria
  • LHON
  • dominant optic atrophy
  • optic neuropathies
  • gene therapy
  • retinal ganglion cell
  • cell therapy
  • pharmacology

Published Papers

This special issue is now open for submission.
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