Special Issue "The Role of P2X Receptors in Nociception, Pain and Neuronal Toxicity"
Deadline for manuscript submissions: 28 February 2022.
Interests: biophysics and molecular dynamics of gating and ion conduction in P2X receptors (P2XR); biophysical effects of pain-associated mutations in voltage-gated sodium channels (NaV); drug screening at P2XR and NaV
Extracellular ATP is an important co-transmitter and neuromodulator in numerous physiological and pathological processes. The targets of extracellular ATP are the nucleotide-activated P2 receptors that can be divided into ionotropic P2X receptors and metabotropic P2Y receptors. Strong evidence suggests that P2X receptors play important roles in sensory transmission and nociception as well as pain. Particularly well established is the crucial role of P2X3- and P2X2/3 receptors in primary sensory neurons or P2X4 receptors in the dorsal horn of the spinal cord in neuropathic and chronic inflammatory pain. P2X7 receptors play an important, but not entirely understood, role in chronic pain.
Some molecular mechanisms via which P2X receptors are involved in the detection and transmission of potentially painful stimuli or modulate nociception and pain have been uncovered, and mediators and signaling molecules involved have been identified. However, major receptor-specific molecular changes or differences in signaling pathways between acute and various chronic forms of pain remain unclear.
Furthermore, P2X receptors are involved in neuronal toxicity. For instance, the P2X7 receptor seems to amplify CNS damage in neurodegenerative diseases. However, the molecular mechanisms of neuronal and glial P2X receptor-mediated toxicity remain largely elusive, even though their overexpression in pathological states seems to be of importance.
The aim and scope of this Special Issue is to present recent research findings or reviews that provide molecular insights into the role of P2X receptors in nociception, pain, and neuronal toxicity, in addition to the underlying molecular mechanisms and signaling pathways.
Dr. Ralf Hausmann
Manuscript Submission Information
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- P2X receptors
- Nociception and pain
- Neuropathic and chronic inflammatory pain
- Neuronal damage and toxicity
- Sensory neurotransmission
- Signaling pathways
- Mediators, neurotransmitters and signaling molecules
- P2X receptor antagonists
- Molecular pharmacology