Special Issue "Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 3.0"
Deadline for manuscript submissions: 30 April 2021.
Interests: drug metabolism; cytochrome P450 structure and mechanism; biological reactive intermediates; thiophene-S-oxides; arene oxides; sulfenic acid; mechanism based inhibitors; Ferrocifen; drug induced immunotoxicity.
Special Issues and Collections in MDPI journals
This Special Issue is a continuation of our previous two Special Issues, “Cytochromes P450: Drug Metabolism and Bioactivation” and “Cytochrome P450: Drug Metabolism and Bioactivation and Biodiversity” (https://0-www-mdpi-com.brum.beds.ac.uk/journal/ijms/special_issues/p450).
Nearly seventy year ago, R.T. Williams and B.B. Brodie developed the concept of drug metabolism and the types of reactions and the mechanisms for the body to facilitate the excretion of a drug. Ten years later, Klingenberg and Garfinkel independently discovered the P450 protein, which was, five years later, demonstrated to be a cytochrome P450 by Omura and Sato. Later on, the prominent function of this enzyme and its role in drug metabolism and endobiotics biosynthesis were established. This resulted in a new chapter, and now more than 90,000 papers contain the concept of cytochrome P450. We are now well aware of this enzyme’s importance in clearance and potential toxicity, and, therefore, compounds do get tested for it. Moreover, this enzyme family is widely distributed in the bacterial, animal, plant, alga and viral kingdoms.
Special Issues 1 and 2 on “Cytochromes P450: Drug Metabolism and Bioactivation” were considerably successful, publishing 14 papers each. Thus, we have decided to launch a new issue with extended topics. This third Special Issue focuses on “Cytochrome P450: Drug Metabolism, Bioactivation, and Biodiversity” and will include papers on: (1) its structures, (2) types and mechanisms of reactions, (3) pharmacogenomics, (4) bioactivation reactions and biological markers, (5) mechanism-based inactivation, (6) species differences, and (7) biodiversity.
We warmly welcome submissions, including original papers and reviews, on these widely-discussed topics.
Dr. Patrick M. Dansette
Prof. Arthur Roberts
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- cytochrome P450
- drug metabolism
- reactive intermediates
- drug induced toxicity
- reaction mechanisms