Special Issue "Cytoprotective Effects of Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) and Related Peptides"
Deadline for manuscript submissions: closed (30 April 2021).
Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide discovered more than thirty years ago from hypothalamic extracts. It belongs to a big peptide family, the vasoactive intestinal peptide (VIP), secretin, glucagon peptide family, acting through G protein-coupled receptors. Early studies already pointed out the robust neurotrophic and neuroprotective effects of PACAP in vitro and in vivo through a combination of antiapototic, anti-inflammatory, and antioxidant effects. Although originally isolated from the central nervous system, and although early studies showed highest concentration in the brain, PACAP also has a very widespread occurrence in peripheral organs. Numerous studies have provided proof that PACAP exerts trophic and protective effects not only in the nervous system but also in several peripheral cell types and organs. The general cytoprotective effects of the peptide also point to the potential of PACAP as a therapeutic agent in numerous toxic, traumatic or ischemic injuries of different cells and tissues. Related peptides, especially VIP, have also been proven to act as protective factors in different cellular and animal models.
The aim of this Special Issue is to gather original and review papers on the general cytoprotective effects of PACAP and related peptides. In vitro, in vivo, and human studies with potential medical importance are all welcome.
Dr. Dora Reglodi
Manuscript Submission Information
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- cellular protection