Special Issue "Peripheral Artery Disease: From Molecular Mechanisms to Therapeutic Approaches"
Deadline for manuscript submissions: 31 December 2021.
Interests: Peripheral Artery Disease; Angiogenesis; Ischemia; Ischemic limb; Diabetes and MicroRNAs
Interests: muscle physiology and biology; oxidative stress; mitochondria biogenesis; angiogenesis; muscle fiber type switching; muscle contractile activity
Special Issues and Collections in MDPI journals
Peripheral artery disease (PAD) refers to atherosclerosis causing impaired blood flow in vessels outside the heart, most commonly affecting arteries of the lower extremities. PAD affects millions of people around the world. There are two classic clinical presentations of PAD: intermittent claudication and critical limb ischemia. Individuals with intermittent claudication typically present with pain with ambulation that is relieved by rest, while those with critical limb ischemia (CLI) present with pain at rest and often have associated ulceration or gangrene. This form of PAD is associated with a high risk of limb amputation and death. The prevalence of PAD is now estimated to be higher than that of ischemic heart disease and cerebrovascular disease combined. Unlike ischemic heart disease and cerebrovascular disease, less is known about the molecular mechanisms driving the development of PAD. Moreover, diabetes, smoking and aging are critical drivers of PAD but how these factors contribute to PAD development and poorer outcomes in PAD is not well known. Currently, there are no effective medical treatments addressing the key issues in PAD, which are impaired blood flow and limb ischemic injury.
This Special Issue of the International Journal of Molecular Sciences aims to bring together the state-of-the-art views and original research on molecular mechanisms in diabetes, smoking or aging contributing to the development of PAD and PAD severity. Intervention to improve blood flow and or limb ischemic injury will also be explored.
Dr. Ayotunde O. Dokun
Dr. Mitsuharu Okutsu
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.