Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.8
5.6
Journals
IJMS
Special Issues
Peripheral Artery Disease: From Molecular Mechanisms to Therapeutic Approaches
ijms-logo
Submit to IJMS Review for IJMS Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Peripheral Artery Disease: From Molecular Mechanisms to Therapeutic Approaches

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 9572

Special Issue Editors

Dr. Ayotunde O. Dokun

E-Mail Website
Guest Editor
Division of Endocrinology and Metabolism, Carver College of Medicine, University of Iowa, Iowa City, IA 52242-1182, USA
Interests: peripheral artery disease; angiogenesis; ischemia; ischemic limb; diabetes and microRNAs
Special Issues, Collections and Topics in MDPI journals
Dr. Mitsuharu Okutsu

E-Mail Website
Guest Editor
Graduate School of Science Division of Biological Science, Nagoya City University, Nagoya, Aichi, Japan
Interests: muscle physiology and biology; oxidative stress; mitochondria biogenesis; angiogenesis; muscle fiber type switching; muscle contractile activity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Peripheral artery disease (PAD) refers to atherosclerosis causing impaired blood flow in vessels outside the heart, most commonly affecting arteries of the lower extremities. PAD affects millions of people around the world. There are two classic clinical presentations of PAD: intermittent claudication and critical limb ischemia. Individuals with intermittent claudication typically present with pain with ambulation that is relieved by rest, while those with critical limb ischemia (CLI) present with pain at rest and often have associated ulceration or gangrene. This form of PAD is associated with a high risk of limb amputation and death. The prevalence of PAD is now estimated to be higher than that of ischemic heart disease and cerebrovascular disease combined. Unlike ischemic heart disease and cerebrovascular disease, less is known about the molecular mechanisms driving the development of PAD. Moreover, diabetes, smoking and aging are critical drivers of PAD but how these factors contribute to PAD development and poorer outcomes in PAD is not well known. Currently, there are no effective medical treatments addressing the key issues in PAD, which are impaired blood flow and limb ischemic injury.

This Special Issue of the International Journal of Molecular Sciences aims to bring together the state-of-the-art views and original research on molecular mechanisms in diabetes, smoking or aging contributing to the development of PAD and PAD severity. Intervention to improve blood flow and or limb ischemic injury will also be explored.

Dr. Ayotunde O. Dokun
Dr. Mitsuharu Okutsu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

18 pages, 4975 KiB  
Article
Modulation of miR-29a and ADAM12 Reduces Post-Ischemic Skeletal Muscle Injury and Improves Perfusion Recovery and Skeletal Muscle Function in a Mouse Model of Type 2 Diabetes and Peripheral Artery Disease
by Victor Lamin, Joseph Verry, Isaac Eigner-Bybee, Jordan D. Fuqua, Thomas Wong, Vitor A. Lira and Ayotunde O. Dokun
Int. J. Mol. Sci. 2022, 23(1), 429; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23010429 - 31 Dec 2021
Cited by 7 | Viewed by 2564
Abstract
Both Type 1 diabetes mellitus (DM1) and type 2 diabetes mellitus (DM2) are associated with an increased risk of limb amputation in peripheral arterial disease (PAD). How diabetes contributes to poor PAD outcomes is poorly understood but may occur through different mechanisms in [...] Read more.
Both Type 1 diabetes mellitus (DM1) and type 2 diabetes mellitus (DM2) are associated with an increased risk of limb amputation in peripheral arterial disease (PAD). How diabetes contributes to poor PAD outcomes is poorly understood but may occur through different mechanisms in DM1 and DM2. Previously, we identified a disintegrin and metalloproteinase gene 12 (ADAM12) as a key genetic modifier of post-ischemic perfusion recovery. In an experimental PAD, we showed that ADAM12 is regulated by miR-29a and this regulation is impaired in ischemic endothelial cells in DM1, contributing to poor perfusion recovery. Here we investigated whether miR-29a regulation of ADAM12 is altered in experimental PAD in the setting of DM2. We also explored whether modulation of miR-29a and ADAM12 expression can improve perfusion recovery and limb function in mice with DM2. Our result showed that in the ischemic limb of mice with DM2, miR-29a expression is poorly downregulated and ADAM12 upregulation is impaired. Inhibition of miR-29a and overexpression of ADAM12 improved perfusion recovery, reduced skeletal muscle injury, improved muscle function, and increased cleaved Tie 2 and AKT phosphorylation. Thus, inhibition of miR-29a and or augmentation of ADAM12 improves experimental PAD outcomes in DM2 likely through modulation of Tie 2 and AKT signalling. Full article
(This article belongs to the Special Issue Peripheral Artery Disease: From Molecular Mechanisms to Therapeutic Approaches)
►▼ Show Figures

Figure 1

Review

Jump to: Research

11 pages, 610 KiB  
Review
The Role of Mitochondrial Function in Peripheral Arterial Disease: Insights from Translational Studies
by Alexandra Gratl, Sabine Wipper, Jan Paul Frese, Ben Raude, Andreas Greiner and Dominik Pesta
Int. J. Mol. Sci. 2021, 22(16), 8478; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22168478 - 06 Aug 2021
Cited by 7 | Viewed by 2805
Abstract
Recent evidence demonstrates an involvement of impaired mitochondrial function in peripheral arterial disease (PAD) development. Specific impairments have been assessed by different methodological in-vivo (near-infrared spectroscopy, 31P magnetic resonance spectroscopy), as well as in-vitro approaches (Western blotting of mitochondrial proteins and enzymes, [...] Read more.
Recent evidence demonstrates an involvement of impaired mitochondrial function in peripheral arterial disease (PAD) development. Specific impairments have been assessed by different methodological in-vivo (near-infrared spectroscopy, 31P magnetic resonance spectroscopy), as well as in-vitro approaches (Western blotting of mitochondrial proteins and enzymes, assays of mitochondrial function and content). While effects differ with regard to disease severity, chronic malperfusion impacts subcellular energy homeostasis, and repeating cycles of ischemia and reperfusion contribute to PAD disease progression by increasing mitochondrial reactive oxygen species production and impairing mitochondrial function. With the leading clinical symptom of decreased walking capacity due to intermittent claudication, PAD patients suffer from a subsequent reduction of quality of life. Different treatment modalities, such as physical activity and revascularization procedures, can aid mitochondrial recovery. While the relevance of these modalities for mitochondrial functional recovery is still a matter of debate, recent research indicates the importance of revascularization procedures, with increased physical activity levels being a subordinate contributor, at least during mild stages of PAD. With an additional focus on the role of revascularization procedures on mitochondria and the identification of suitable mitochondrial markers in PAD, this review aims to critically evaluate the relevance of mitochondrial function in PAD development and progression. Full article
(This article belongs to the Special Issue Peripheral Artery Disease: From Molecular Mechanisms to Therapeutic Approaches)
►▼ Show Figures

Figure 1

16 pages, 950 KiB  
Review
Outcomes of Lower Extremity Endovascular Revascularization: Potential Predictors and Prevention Strategies
by Federico Biscetti, Elisabetta Nardella, Maria Margherita Rando, Andrea Leonardo Cecchini, Antonio Gasbarrini, Massimo Massetti and Andrea Flex
Int. J. Mol. Sci. 2021, 22(4), 2002; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22042002 - 18 Feb 2021
Cited by 23 | Viewed by 3463
Abstract
Peripheral artery disease (PAD) is a manifestation of atherosclerosis, which may affect arteries of the lower extremities. The most dangerous PAD complication is chronic limb-threatening ischemia (CLTI). Without revascularization, CLTI often causes limb loss. However, neither open surgical revascularization nor endovascular treatment (EVT) [...] Read more.
Peripheral artery disease (PAD) is a manifestation of atherosclerosis, which may affect arteries of the lower extremities. The most dangerous PAD complication is chronic limb-threatening ischemia (CLTI). Without revascularization, CLTI often causes limb loss. However, neither open surgical revascularization nor endovascular treatment (EVT) ensure long-term success and freedom from restenosis and revascularization failure. In recent years, EVT has gained growing acceptance among all vascular specialties, becoming the primary approach of revascularization in patients with CLTI. In clinical practice, different clinical outcomes after EVT in patients with similar comorbidities undergoing the same procedure (in terms of revascularization technique and localization of the disease) cause unsolved issues that need to be addressed. Nowadays, risk management of revascularization failure is one of the major challenges in the vascular field. The aim of this literature review is to identify potential predictors for lower extremity endovascular revascularization outcomes and possible prevention strategies. Full article
(This article belongs to the Special Issue Peripheral Artery Disease: From Molecular Mechanisms to Therapeutic Approaches)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop