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Special Issue "The PI3K/AKT/mTOR Signalling Network in Cancer Drug Resistance"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 15 September 2021.

Special Issue Editor

Dr. Claudia Pivonello
E-Mail Website
Guest Editor
Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy
Interests: Neuroendocrinology; drug resistance; vitamin D; circadian rhythm; mTOR pathway; miRNAs; exosomes

Special Issue Information

Dear Colleagues,

The PI3K/Akt/mTOR signaling pathway is a core cellular component that plays a critical role in the regulation of cell growth and proliferation, survival, motility, differentiation, angiogenesis, and metabolism. Hyperactivation of PI3K signaling, due to mutations causing gain of protein function in the several components of the PI3K pathway (PIK3CA, PTEN, AKT), is an almost universal hallmark of cancer and of drug resistance.

This Special Issue, entitled “The PI3K/AKT/mTOR Signaling Network in Cancer Drug Resistance”, will collect 10 articles written by international researchers from different countries with an outstanding research background in the field and will aim at gathering evidence from preclinical studies encompassing the pathogenic role of the PI3K/AKT/mTOR signaling pathway in cancer onset and drug resistance.

Deepening our understanding of molecular mechanisms such as miRNA- and exosomes-mediated PI3K/AKT/mTOR pathway regulation, the role of the PI3K/AKT/mTOR pathway in cancer stem cells, and tumor microenvironment function in cancer drug resistance will help to provide new insights which are mandatory to develop new approaches in individualized target therapies.

Emphasis will be given to the molecular facets of PI3K/AKT/mTOR in cancer and drug resistance. Original preclinical studies and review articles on molecular mechanisms are welcome.

Dr. Claudia Pivonello
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • PI3K pathway
  • mTOR
  • AKT
  • drug resistance
  • cancer
  • miRNA
  • exosome
  • cancer stem cells
  • cell migration
  • epithelial–mesenchymal transition

Published Papers

This special issue is now open for submission.
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