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Special Issue "Zinc-Finger Proteins in Health and Disease: Focus on PRDMs"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: closed (30 June 2020).

Special Issue Editors

Prof. Dr. Bruno Moncharmont
E-Mail Website
Guest Editor
Università degli studi del Molise, Italy
Interests: cancer; PRDM genes; nuclear receptors
Dr. Erika Di Zazzo
E-Mail Website1 Website2
Guest Editor
Department of Medicine and Health Science, University of Molise, 86100 Campobasso, Italy
Interests: cancers; PRDM genes; steroid receptors; signal transduction
Special Issues and Collections in MDPI journals
Prof. Dr. Ciro Abbondanza
E-Mail Website
Guest Editor
Dipartimento di Medicina di Precisione, Università degli studi della Campania "L. Vanvitelli", Italy
Interests: cancers; PRDM genes; steroid receptors
Special Issues and Collections in MDPI journals
Dr. Monica Rienzo
E-Mail Website
Guest Editor

Special Issue Information

Dear Colleagues,

Proteins containing Zinc-finger domain(s) are able to mediate the interaction with DNA, RNA, and other proteins. They are implicated in transcriptional regulation, ubiquitin-mediated protein degradation, signal transduction, DNA repair, cell migration, and numerous other processes.

These proteins often contain multiple additional domains other than zinc-fingers. Indeed, in metazoan zinc-finger domains are rarely found alone; usually, they form tandem arrays and sometimes they combine with different domains thus increasing their complexity and potential functions. For instance, members of the positive regulatory domain (PRDM) family gene are characterized by a PR domain, related to the SET methyltransferase domain, and multiple zinc fingers motifs. PRDM proteins are transcriptional regulators which are highly cell type and tissue peculiar and which modulate the expression of target genes by modifying the chromatin structure either directly, through their intrinsic methyltransferase activity, or indirectly, through the recruitment of specific chromatin remodeling complexes. The PRDM gene family is involved in a broad spectrum of biological processes, including proliferation and differentiation control, cell cycle progression, and maintenance of immune cell homeostasis, being implicated in the transduction of several signals. Additionally, PRDMs are able to contribute to many developmental processes, controlling cell differentiation and maturation events, cell commitment, as well as cell stemness. Remarkably, genetic and epigenetic alterations of several PRDM family members have been frequently observed in cancer. Overall, the PRDM gene family is involved in several human diseases and could represent a molecular marker for diagnosis and prognosis and a promising target for therapy. We invite authors to submit both original research articles and review articles that cover recent research advances in the understanding of the molecular mechanisms of transcriptional regulation and main processes controlled by Zn finger proteins during the development, cell homeostasis maintenance, as well as in the onset and progression of human disease.

 

Prof. Dr. Bruno Moncharmont
Dr. Erika Di Zazzo
Prof. Dr. Ciro Abbondanza
Dr. Amelia Casamassimi
Dr. Monica Rienzo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • PRDM genes
  • cancer
  • human diseases
  • proliferation
  • differentiation
  • gene expression regulation
  • apoptosis

Published Papers (2 papers)

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Review

Review
NRF2, a Transcription Factor for Stress Response and Beyond
Int. J. Mol. Sci. 2020, 21(13), 4777; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21134777 - 06 Jul 2020
Cited by 35 | Viewed by 1806
Abstract
Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the cellular defense against toxic and oxidative insults through the expression of genes involved in oxidative stress response and drug detoxification. NRF2 activation renders cells resistant to chemical carcinogens and [...] Read more.
Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the cellular defense against toxic and oxidative insults through the expression of genes involved in oxidative stress response and drug detoxification. NRF2 activation renders cells resistant to chemical carcinogens and inflammatory challenges. In addition to antioxidant responses, NRF2 is involved in many other cellular processes, including metabolism and inflammation, and its functions are beyond the originally envisioned. NRF2 activity is tightly regulated through a complex transcriptional and post-translational network that enables it to orchestrate the cell’s response and adaptation to various pathological stressors for the homeostasis maintenance. Elevated or decreased NRF2 activity by pharmacological and genetic manipulations of NRF2 activation is associated with many metabolism- or inflammation-related diseases. Emerging evidence shows that NRF2 lies at the center of a complex regulatory network and establishes NRF2 as a truly pleiotropic transcription factor. Here we summarize the complex regulatory network of NRF2 activity and its roles in metabolic reprogramming, unfolded protein response, proteostasis, autophagy, mitochondrial biogenesis, inflammation, and immunity. Full article
(This article belongs to the Special Issue Zinc-Finger Proteins in Health and Disease: Focus on PRDMs)
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Review
Multifaceted Role of PRDM Proteins in Human Cancer
Int. J. Mol. Sci. 2020, 21(7), 2648; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21072648 - 10 Apr 2020
Cited by 11 | Viewed by 1535
Abstract
The PR/SET domain family (PRDM) comprise a family of genes whose protein products share a conserved N-terminal PR [PRDI-BF1 (positive regulatory domain I-binding factor 1) and RIZ1 (retinoblastoma protein-interacting zinc finger gene 1)] homologous domain structurally and functionally similar to the catalytic SET [...] Read more.
The PR/SET domain family (PRDM) comprise a family of genes whose protein products share a conserved N-terminal PR [PRDI-BF1 (positive regulatory domain I-binding factor 1) and RIZ1 (retinoblastoma protein-interacting zinc finger gene 1)] homologous domain structurally and functionally similar to the catalytic SET [Su(var)3-9, enhancer-of-zeste and trithorax] domain of histone methyltransferases (HMTs). These genes are involved in epigenetic regulation of gene expression through their intrinsic HMTase activity or via interactions with other chromatin modifying enzymes. In this way they control a broad spectrum of biological processes, including proliferation and differentiation control, cell cycle progression, and maintenance of immune cell homeostasis. In cancer, tumor-specific dysfunctions of PRDM genes alter their expression by genetic and/or epigenetic modifications. A common characteristic of most PRDM genes is to encode for two main molecular variants with or without the PR domain. They are generated by either alternative splicing or alternative use of different promoters and play opposite roles, particularly in cancer where their imbalance can be often observed. In this scenario, PRDM proteins are involved in cancer onset, invasion, and metastasis and their altered expression is related to poor prognosis and clinical outcome. These functions strongly suggest their potential use in cancer management as diagnostic or prognostic tools and as new targets of therapeutic intervention. Full article
(This article belongs to the Special Issue Zinc-Finger Proteins in Health and Disease: Focus on PRDMs)
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