Molecular Biology of Parathyroid Tumors
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 8865
Special Issue Editor
Interests: parathyroid diseases; bone metabolism disorders
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear colleagues,
Parathyroid tumors are the second most common endocrine neoplasia. They are mainly benign lesions associated with parathormone (PTH) inappropriate secretion, determining the metabolic disorder known as primary hyperparathyroidism (PHPT). Parathyroid tumors are characterized by calcium-sensing receptor (CASR)-mediated reduced sensitivity to extracellular calcium. Genetic and epigenetic alterations resulting in aberrant expression of protein-coding and non-coding genes have been identified in parathyroid tumors. Besides inactivating mutations of the oncosuppressors MEN1 and HRPT2/CDC73, epigenetic changes have been reported. Impaired DNA methylation involving single genes, the deregulated expression of microRNAs, and long noncoding RNAs have started to be to be investigated. However, many aspects of the molecular biology of the parathyroid tumors need to be explored, such as the molecular pathways related to the genetic and epigenetic aberrations, and their effects on parathyroid cell proliferation and/or sensitivity to extracellular calcium, in order to provide targets for new therapeutic approaches, which are lacking.
The Special Issue aims to widely explore the molecular and biological features of parathyroid tumorigenesis, focusing on genetic and epigenetic aspects, parathyroid cell proliferation and biology, tumor microenvironment, CASR-mediated sensitivity to extracellular calcium, deregulation of the PTH release, and the differences between the benign and malignant behavior of the parathyroid cells, considering original articles and review papers.
Prof. Dr. Sabrina Corbetta
Guest Editor
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Keywords
- Parathyroi adenomas
- Parathyroid cancers
- MEN1
- CDC73
- Calcium sensing receptor (CASR)
- microRNAs
- methylation
- LncRNAs
- Epigenetics
- PTH
- Parathyroid cell proliferation
