Special Issue "Molecular Biology of Parathyroid Tumors"
Deadline for manuscript submissions: closed (31 December 2020).
Interests: primary hyperparathyroidism; Calcium-sensing receptor; parathyroid tumors; microRNAs; MEN1; osteoporosis
Special Issues and Collections in MDPI journals
Parathyroid tumors are the second most common endocrine neoplasia. They are mainly benign lesions associated with parathormone (PTH) inappropriate secretion, determining the metabolic disorder known as primary hyperparathyroidism (PHPT). Parathyroid tumors are characterized by calcium-sensing receptor (CASR)-mediated reduced sensitivity to extracellular calcium. Genetic and epigenetic alterations resulting in aberrant expression of protein-coding and non-coding genes have been identified in parathyroid tumors. Besides inactivating mutations of the oncosuppressors MEN1 and HRPT2/CDC73, epigenetic changes have been reported. Impaired DNA methylation involving single genes, the deregulated expression of microRNAs, and long noncoding RNAs have started to be to be investigated. However, many aspects of the molecular biology of the parathyroid tumors need to be explored, such as the molecular pathways related to the genetic and epigenetic aberrations, and their effects on parathyroid cell proliferation and/or sensitivity to extracellular calcium, in order to provide targets for new therapeutic approaches, which are lacking.
The Special Issue aims to widely explore the molecular and biological features of parathyroid tumorigenesis, focusing on genetic and epigenetic aspects, parathyroid cell proliferation and biology, tumor microenvironment, CASR-mediated sensitivity to extracellular calcium, deregulation of the PTH release, and the differences between the benign and malignant behavior of the parathyroid cells, considering original articles and review papers.
Prof. Dr. Sabrina Corbetta
Manuscript Submission Information
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- Parathyroi adenomas
- Parathyroid cancers
- Calcium sensing receptor (CASR)
- Parathyroid cell proliferation