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Special Issue "Role of Nrf2/Keap1 Signaling Pathway in Human Diseases"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 June 2021.

Special Issue Editor

Dr. Eun-Hee Kim
Guest Editor
Department of Pharmacy, College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, 120 Haeryong-ro, Pocheon 11160, Korea
Interests: Nrf2; Keap1; reactive oxygen species; oxidative stress; inflammation; cancer; gastrointestinal tract; chemoprevention; cancer metabolism; metastasis
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

The nuclear factor, erythroid 2-like transcription factor 2 (Nrf2), and its cytoplasmic repressor, kelch-like ECH-associated protein 1 (Keap1), regulate the expression of the antioxidant and cytoprotective genes so as to maintain redox homeostasis. The Nrf2/Keap1 pathway is an important signaling cascade responsible for the resistance of oxidative damage, exerts anti-inflammation and anticancer activity by regulating its multiple downstream cytoprotective genes, thereby plays a vital role in cell survival. Research in the molecular biology, biochemistry, and related basic fields of the Nrf2/Keap1 pathway are still very active, Nrf2-related research are expanding into more clinical areas such as cardiology, nephrology, endocrinology, and metabolism. Interestingly, in recent years, evidence is sccumulating that Nrf2 plays a contradictory role in cancers. Aberrant activation of Nrf2 promotes cancer cell proliferation by metabolic reprogramming and repression of cancer cell apoptosis, and contributes to the chemoresistance of cancer cells as well as inflammation-induced carcinogenesis. Therefore, understanding the role and regulatory molecular mechanism of Nrf2/Keap1 pathway in varous human diseases including cancer may be an effective strategy for the development of novel therapeutic approaches to varous disorders including cancer. In this Special Issue of International Journal of Molecular Sciences, “Role of Nrf2/Keap1 signaling pathway in human diseases”,  experts are invited to contribute original research papers or review articles will provide further insights on the role of Nrf2/Keap1 signaling pathway in human diseases.

Dr. Eun-Hee Kim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Nrf2
  • Keap1
  • Reactive oxygen species
  • Oxidative stress
  • Redox signaling
  • Inflammation
  • Cancer
  • Chemoprevention
  • Chemoresistance
  • Proliferation
  • Apoptosis
  • Metastasis

Published Papers

This special issue is now open for submission.
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