Special Issue "Role of Nrf2/Keap1 Signaling Pathway in Human Diseases"
Deadline for manuscript submissions: 30 June 2021.
Interests: Nrf2; Keap1; reactive oxygen species; oxidative stress; inflammation; cancer; gastrointestinal tract; chemoprevention; cancer metabolism; metastasis
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The nuclear factor, erythroid 2-like transcription factor 2 (Nrf2), and its cytoplasmic repressor, kelch-like ECH-associated protein 1 (Keap1), regulate the expression of the antioxidant and cytoprotective genes so as to maintain redox homeostasis. The Nrf2/Keap1 pathway is an important signaling cascade responsible for the resistance of oxidative damage, exerts anti-inflammation and anticancer activity by regulating its multiple downstream cytoprotective genes, thereby plays a vital role in cell survival. Research in the molecular biology, biochemistry, and related basic fields of the Nrf2/Keap1 pathway are still very active, Nrf2-related research are expanding into more clinical areas such as cardiology, nephrology, endocrinology, and metabolism. Interestingly, in recent years, evidence is sccumulating that Nrf2 plays a contradictory role in cancers. Aberrant activation of Nrf2 promotes cancer cell proliferation by metabolic reprogramming and repression of cancer cell apoptosis, and contributes to the chemoresistance of cancer cells as well as inflammation-induced carcinogenesis. Therefore, understanding the role and regulatory molecular mechanism of Nrf2/Keap1 pathway in varous human diseases including cancer may be an effective strategy for the development of novel therapeutic approaches to varous disorders including cancer. In this Special Issue of International Journal of Molecular Sciences, “Role of Nrf2/Keap1 signaling pathway in human diseases”, experts are invited to contribute original research papers or review articles will provide further insights on the role of Nrf2/Keap1 signaling pathway in human diseases.
Dr. Eun-Hee Kim
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- Reactive oxygen species
- Oxidative stress
- Redox signaling