Special Issue "Therapeutic Peptides on Plasmonic Nanoparticles"
Deadline for manuscript submissions: closed (30 September 2021).
Interests: biomolecular structure; peptides, proteins and nucleic acids; physicochemical properties of therapeutic agents; elaboration and functionalization of plasmonic nanoparticles; use of plasmonic nanoparticles to probe cell receptors and enzymatic activity; surface-enhanced Raman scattering; optical spectroscopy; statistic and dynamic quantum mechanical calculations on the molecules of biological interest
Optical spectroscopic techniques, based on the absorption, emission, or scattering of the electromagnetic radiation within the ultraviolet-visible-infrared range, is now routinely applied to biological systems for analyzing their chemical composition, molecular interactions, and structural dynamics. These techniques are basically characterized by their rapid acquisition and post-record treatment of the spectroscopic data, as well as the shortness of the time scale (<10-12 sec) that they are able to access. The combined use of the optical techniques, for instance those based on the analysis of the vibrational motions (Raman scattering, ROA, IR absorption, VCD) with the others using the electronic transitions (UV-absorption and UV-CD), leads to a wide scope of the structural and environmental changes occurring inside a biological system. The combination of spectroscopy and nanotechnology leads to a huge enhancement of the sensitivity of the above techniques. Plasmonic effects induced by flat surfaces through surface plasmon-polaritons, or on nanostructured metallic systems where localized surface plasmon resonance leads to significant intensification of spectroscopic signals (Raman, fluorescence, IR absorption) from biomolecules in the vicinity of nanostructures. These surface techniques, mainly SERS, have been extensively applied in the detection of biomolecules and the implementation of therapeutic strategies.
Prof. Mahmoud Ghomi
Manuscript Submission Information
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- Structural dynamics
- Plasmonic nanoparticles
- Optical spectroscopy
- Surface-enhanced Raman scattering