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Special Issue "Phagocytosis: Current Understanding, Recent Developments, and Future Perspectives"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 28 February 2022.

Special Issue Editor

Dr. Sharon Dewitt
E-Mail Website
Guest Editor
Matrix Biology and Tissue Repair, College of Biomedical and Life Sciences, School of Dentistry, Cardiff University, Cardiff, UK
Interests: neutrophil biology; phagocytosis; extravasation; chemotaxis; apoptosis; inflammation; immunology of infectious diseases; innate immunity; cell-matrix interactions; calcium signalling; cell signalling; arthritis; tissue engineering; single cell imaging; micromanipulation/microinjection; biomarkers

Special Issue Information

Dear Colleagues,

Phagocytosis is the incredible cellular event by which cells internalise particulate material larger than about 0.5 µm in diameter. Many cells are capable of phagocytosis, for nutrition or tissue homeostasis, but certain specialised cells (such as neutrophils, macrophages, monocytes, dendritic cells, osteoclasts, etc) internalise particulate matter with high efficiency, earning them the title ‘professional phagocytes’. The process involves a complex and coordinated series of molecular and biological events that terminate in the internalised material (often pathogenic microorganisms) being removed from the host and destroyed. Initially, particle recognition and binding occur through cell surface receptors, which trigger intracellular signalling pathways and cellular responses, including remodelling of the actin cytoskeleton and changes to the membrane composition, charge, and tension. The resulting morphological change is particularly dramatic when observed: dynamic pseudopodia emerge from the cell, progressively enclose the particle, then fuse to form a specialised vacuole, called a phagosome, that contains the target. Once internalised, the cells killing mechanisms are activated, including the directed release of degradative enzymes into the phagosome and the controlled production of reactive oxygen species.

Although phagocytosis was first described in the eighteenth century, new approaches, multidisciplinary collaborations, ‘out of the box’ thinking, and of course recent advances in technology, probes and sensors, have dramatically increased our progress and knowledge in each of these complex areas.

This Special Issue on “Phagocytosis” aims to provide a summary of what already know about the molecular and cell biology of phagocytosis, but also to report the recent progress, latest developments in our understanding and advances in the techniques available to probe these complex mechanisms.

This Special Issue will publish original research articles as well as full reviews, perspectives on the current understanding of molecular mechanisms involved, and on the many questions that remain open.

I encourage colleagues with an interest and passion for phagocytosis to contribute to this collection, to stimulate further conversation and motivate the future generation of researchers in this exciting field.

Dr. Sharon Dewitt
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • phagocytosis
  • phagocyte
  • recruitment
  • receptors
  • FcR
  • complement
  • opsonins
  • neutrophils
  • macrophages
  • monocytes
  • dictyostelium
  • NADPH oxidase
  • ROS
  • microscopy
  • phosphoinositides phagosome
  • electrostatic
  • surface potential
  • modelling
  • calpain
  • actin
  • membrane tension
  • signalling
  • Ca2+
  • inflammation
  • innate immunity
  • molecular mechanisms
  • inflammatory diseases

Published Papers

This special issue is now open for submission.
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