Special Issue "Phagocytosis: Current Understanding, Recent Developments, and Future Perspectives"
Deadline for manuscript submissions: 28 February 2022.
Interests: neutrophil biology; phagocytosis; extravasation; chemotaxis; apoptosis; inflammation; immunology of infectious diseases; innate immunity; cell-matrix interactions; calcium signalling; cell signalling; arthritis; tissue engineering; single cell imaging; micromanipulation/microinjection; biomarkers
Phagocytosis is the incredible cellular event by which cells internalise particulate material larger than about 0.5 µm in diameter. Many cells are capable of phagocytosis, for nutrition or tissue homeostasis, but certain specialised cells (such as neutrophils, macrophages, monocytes, dendritic cells, osteoclasts, etc) internalise particulate matter with high efficiency, earning them the title ‘professional phagocytes’. The process involves a complex and coordinated series of molecular and biological events that terminate in the internalised material (often pathogenic microorganisms) being removed from the host and destroyed. Initially, particle recognition and binding occur through cell surface receptors, which trigger intracellular signalling pathways and cellular responses, including remodelling of the actin cytoskeleton and changes to the membrane composition, charge, and tension. The resulting morphological change is particularly dramatic when observed: dynamic pseudopodia emerge from the cell, progressively enclose the particle, then fuse to form a specialised vacuole, called a phagosome, that contains the target. Once internalised, the cells killing mechanisms are activated, including the directed release of degradative enzymes into the phagosome and the controlled production of reactive oxygen species.
Although phagocytosis was first described in the eighteenth century, new approaches, multidisciplinary collaborations, ‘out of the box’ thinking, and of course recent advances in technology, probes and sensors, have dramatically increased our progress and knowledge in each of these complex areas.
This Special Issue on “Phagocytosis” aims to provide a summary of what already know about the molecular and cell biology of phagocytosis, but also to report the recent progress, latest developments in our understanding and advances in the techniques available to probe these complex mechanisms.
This Special Issue will publish original research articles as well as full reviews, perspectives on the current understanding of molecular mechanisms involved, and on the many questions that remain open.
I encourage colleagues with an interest and passion for phagocytosis to contribute to this collection, to stimulate further conversation and motivate the future generation of researchers in this exciting field.
Dr. Sharon Dewitt
Manuscript Submission Information
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