Special Issue "Molecular Mechanisms and Pharmacological Targeting of Neuroprotection"
Deadline for manuscript submissions: 31 October 2021.
Interests: neuropsychopharmacology; anxyolitics; neurodegenerative diseases; depression
Interests: medicinal chemistry; peptidomimetics; drug-based peptide design; dipeptide drugs; neuropeptide; neurotrophine
The complex pathophysiology of neurodegenerative diseases, as well as the consequences of acute or chronic ischemic brain injury, age-dependent cognitive deficiency and neurological disorders caused by or associated with COVID-19 infection, generally involves damage of neurons and glial cells, synaptic dysfunction and a decrease in neuroplasticity. The molecular mechanisms behind those alterations are related to disturbances in signaling processes at the level of cell surface receptors, intracellular signal transduction cascades, excitotoxicity, epigenetic changes, impaired bioenergetics and imbalance of pro- and antioxidant functions, neuroinflammation, improper protein folding and aggregation.
In this Special Issue, we welcome original research and review papers that address new approaches to the pharmacological regulation of neuroprotection that target receptors, including tyrosine kinase receptors, and intracellular signaling pathways, which enhance neuroplasticity. Additionally, authors are welcome to submit articles discussing current studies regarding the regulation of endogenous protective mechanisms, such as production of neurosteroids, hypoxia response mechanisms and chaperones’ functions. Special attention to original synthetic small molecules, monoclonal antibodies and peptidomimetics, which affect the neuroprotective pathways will be also paid.
Prof. Dr. Sergei B. Seredenin
Prof. Dr. Tatiana A. Gudasheva
Dr. Yulia V. Vakhitova
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Sigma1R chaperon
- glutamate dysregulation