Special Issue "Phytochemicals for Diabetes and its Complication"
Deadline for manuscript submissions: 31 May 2021.
This special issue deals with the latest advances in knowledge and ongoing research on the effects of phytochemicals on renal function in health and diabetes. Phytochemicals posesses therapeutic activities of antiapoptotic, antioxidative, antidiabetic, and antiinflammatory effects. Several phytochemicals exhibit renoprotective actions in diseases such as diabetic nephropathy, diabetes-associated chronic kidney disease, glomerulonephritis, and glomeulosclerosis. Phytochemicals manipulate diverse renal factors and attenuate the renal injury associated with diabetes. Their therapeutic outcomes derive from their interference with multiple signaling pathways known to produce renal injury. There are various mechanisms by which renoprotection may be achieved, including increase in production of advanced glycation end-products (AGEs), oxidative stress, and activation of hexosamine flux, causing inflammation and kidney injury. Increase in formation of AGEs and oxidative stress may result in an increase in production of proteins o f mesangial cells and macrophages extracellular matrix as well as in endothelial cells. Some phytochemicals disturb the handling mechanisms of tubular transport processes in the proximal and distal tubules by alteration of the structural integrity and function of tubules. ER stress, apoptosis and autophagy would be ones of the main causes of diabetes-associated kidney dysfunction. In this mechanistic regard, the beneficial effects of phytochemicals need to be established.
Prof. Dr. Young-Hee Kang
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Phytochemicals and Diabetes
- Chronic Kidney Disease
- Diabetic Nephropathy
- Vascular Complications
- Cell Death
- ER Stress
- Oxidative Stress
- Advanced Glycation End-Products