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Special Issue "RNA-Binding Proteins and Their Emerging Roles in Cancer"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 28 February 2021.

Special Issue Editors

Dr. John Murphy
Website
Guest Editor
Faculty of Science and Technology, University of Westminster, London, United Kingdom
Interests: RNA-Binding Proteins and Cancer
Dr. Kalpana Surendranath
Website
Guest Editor
Faculty of Science and Technology, University of Westminster, London, United Kingdom
Interests: RNA-DNA Damage Response and Cancer
Dr. Radhakrishnan Kanagaraj
Website
Guest Editor
Faculty of Science and Technology, University of Westminster, London, United Kingdom
Interests: RNA/DNA Secondary Structures; Genomic Instability and Human Disease

Special Issue Information

Dear Colleagues,

The human genome encodes more than 1500 RNA-binding proteins (RBPs), and the number is expected to increase with the addition of RBPs that contain non-canonical RNA binding motifs. These proteins are at the center of transcriptional and post-transcriptional regulation of gene expression and play a central role in all four highly regulated interconnected pathways, namely: transcriptional responses, RNA–DNA damage responses, and DNA repair and apoptosis. Mutations in several RBPs have been linked to cancers, and therefore, RBPs and their associated pathways are potential drug targets. Increasing evidence from research in the past decade highlights the intricate interplay between RNA metabolism, RNA binding proteins, and genome stability in human health and disease. The proposed issue will broadly cover the following topics:

  • RNA-binding proteins in RNA metabolism;
  • RNA-binding proteins in RNA–DNA damage response;
  • RNA-binding proteins in cancer-associated instability;
  • New technologies to study RNA-binding proteins and RNA/DNA secondary structures;
  • Unresolved RNA/DNA secondary structures and genomic instability.

Dr. John Murphy
Dr. Kalpana Surendranath
Dr. Radhakrishnan Kanagaraj
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • transcription
  • gene expression
  • RNA splicing
  • RNA editing
  • non-coding RNA
  • R-loop
  • G-quadruplex
  • RNA–DNA damage
  • DNA repair
  • genome instability
  • mutation
  • cancer

Published Papers (1 paper)

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Research

Open AccessArticle
MBNL2 Regulates DNA Damage Response via Stabilizing p21
Int. J. Mol. Sci. 2021, 22(2), 783; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22020783 - 14 Jan 2021
Abstract
RNA-binding proteins are frequently dysregulated in human cancer and able to modulate tumor cell proliferation as well as tumor metastasis through post-transcriptional regulation on target genes. Abnormal DNA damage response and repair mechanism are closely related to genome instability and cell transformation. Here, [...] Read more.
RNA-binding proteins are frequently dysregulated in human cancer and able to modulate tumor cell proliferation as well as tumor metastasis through post-transcriptional regulation on target genes. Abnormal DNA damage response and repair mechanism are closely related to genome instability and cell transformation. Here, we explore the function of the RNA-binding protein muscleblind-like splicing regulator 2 (MBNL2) on tumor cell proliferation and DNA damage response. Transcriptome and gene expression analysis show that the PI3K/AKT pathway is enriched in MBNL2-depleted cells, and the expression of cyclin-dependent kinase inhibitor 1A (p21CDKN1A) is significantly affected after MBNL2 depletion. MBNL2 modulates the mRNA and protein levels of p21, which is independent of its canonical transcription factor p53. Moreover, depletion of MBNL2 increases the phosphorylation levels of checkpoint kinase 1 (Chk1) serine 345 (S345) and DNA damage response, and the effect of MBNL2 on DNA damage response is p21-dependent. MBNL2 would further alter tumor cell fate after DNA damage, MBNL2 knockdown inhibiting DNA damage repair and DNA damage-induced senescence, but promoting DNA damage-induced apoptosis. Full article
(This article belongs to the Special Issue RNA-Binding Proteins and Their Emerging Roles in Cancer)
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