Special Issue "Mitochondrial DNA and RNA in Human Disease"
Deadline for manuscript submissions: 30 November 2021.
A greater understanding of the mechanisms of mtDNA expression is clearly necessary to unravel the complex role of mitochondria in human disease and aging. In humans, mtDNA is a circular 16.6 kb that encodes a small subset of proteins required for efficient oxidative phosphorylation activity. Many mutations in mtDNA that affect the expression of mitochondria-encoded oxidative phosphorylation components are associated with human pathologies, collectively known as mitochondrial disease. Recent growing evidence also suggests that defects in the nuclear genes encoding proteins involved in mitochondrial gene expression are also a leading cause of human mitochondrial disease. Among these nuclear encoded proteins are factors required for mitochondrial transcription, RNA processing, and translation. It would be remarkably interesting to discuss the most recent advances in our understanding of the post-transcriptional processes of mtDNA gene expression, which represents an emerging field of research—in particular, the recent discovery of novel factors required for modification and maturation of mtRNAs, the characterization of mtRNA granules as sites for organization of mtRNA processing, the biogenesis and composition of the mitoribosomes, and the coordination required for concerted nuclear and mitochondrial gene expression.
Dr. Maria Simarro Grande
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- RNA processing
- RNA granules