Special Issue "RNA Modification Dynamics in Cellular Dysregulation and Clinical Diseases"
Deadline for manuscript submissions: 31 August 2021.
Looking back on the developing trends in the field of epigenetics, modification on histones, DNA and RNA one after another demonstrates their role in orchestrating cell fates. RNA modification is of note, the recent hot topic that has been linked toward regulation of ontogeny, hematopoiesis, inflammation and immunity commitment. Strikingly, the decoration of RNA was found not merely a simple chemical additive to nucleotide, but a powerful switch that harness spatiotemporal conformation of the gene transcriptome. In this Special Issue, we will include original articles and comprehensive reviews to elucidate how RNA modifications such as m6A, m1A, and m7G could link RNA dynamics toward cellular dysregulation and diseases. To date, more than 160 chemical modifications on ribonucleosides have been identified. They exist on ribosomal RNA, transfer RNA, messenger RNA and various noncoding RNAs. Similarly to epigenetic modifications on histones and DNA, modifications on RNA could regulate gene expression and phenotypes without affecting the DNA sequence. Hence, RNA modifications have been considered as a new defined fine-tuning layer as to the gene regulation. Thus, many dysregulation of RNA modifications have been linked toward disturbed cellular homeostasis. In order to provide readers with a holistic view of the influence of RNA modifications in cellular dysfunction, authors from this Special Issue will address their research experience in terms of bio-chemical techniques, phenotypic characterization and strategies in the molecular biology approach.
Prof. Dr. Shih-Hwa Chiou
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- RNA modification
- Cellular stress response
- Epi-transcriptomes in disease models