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Special Issue "RNA Modification Dynamics in Cellular Dysregulation and Clinical Diseases"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 August 2021.

Special Issue Editor

Prof. Dr. Shih-Hwa Chiou
E-Mail Website
Guest Editor
Genomics Research Ceter, Academia Sinica, National Yang-Ming University, Taipei, Taiwan
Interests: epigenetics; stem cell biology; genetic engineering in translational medicine

Special Issue Information

Dear Colleagues,

Looking back on the developing trends in the field of epigenetics, modification on histones, DNA and RNA one after another demonstrates their role in orchestrating cell fates. RNA modification is of note, the recent hot topic that has been linked toward regulation of ontogeny, hematopoiesis, inflammation and immunity commitment. Strikingly, the decoration of RNA was found not merely a simple chemical additive to nucleotide, but a powerful switch that harness spatiotemporal conformation of the gene transcriptome. In this Special Issue, we will include original articles and comprehensive reviews to elucidate how RNA modifications such as m6A, m1A, and m7G could link RNA dynamics toward cellular dysregulation and diseases. To date, more than 160 chemical modifications on ribonucleosides have been identified. They exist on ribosomal RNA, transfer RNA, messenger RNA and various noncoding RNAs. Similarly to epigenetic modifications on histones and DNA, modifications on RNA could regulate gene expression and phenotypes without affecting the DNA sequence. Hence, RNA modifications have been considered as a new defined fine-tuning layer as to the gene regulation. Thus, many dysregulation of RNA modifications have been linked toward disturbed cellular homeostasis. In order to provide readers with a holistic view of the influence of RNA modifications in cellular dysfunction, authors from this Special Issue will address their research experience in terms of bio-chemical techniques, phenotypic characterization and strategies in the molecular biology approach.

Prof. Dr. Shih-Hwa Chiou
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • RNA modification
  • Cellular stress response
  • Epi-transcriptomes in disease models

Published Papers

This special issue is now open for submission.
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