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RNPs (Ribonucleoproteins) in Human Physiology and Disease Processes
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RNPs (Ribonucleoproteins) in Human Physiology and Disease Processes

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (15 March 2021) | Viewed by 2690

Special Issue Editor

Dr. Je-Hyun Yoon

E-Mail Website
Guest Editor
Department of Biochemistry and Molecular Biology, Medical University of South Carolina, 173 Ashley Avenue, BSB 512B, MSC 509, Charleston, SC 29425, USA
Interests: RNA-binding protein; RNA localizatoin; noncoding RNA; mRNA decay; mRNA translation; splicing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue aims to collect—from the broadest context—original research and review articles on the functions of RNPs (Ribonucleoproteins) in Human Physiology and Disease Processes. Furthermore, this Special Issue systematically highlights the roles of RNA-binding proteins and noncoding RNAs in regulation of RNA localization, splicing, decay, and translation in contributing to normal physiology and pathology. This issue will contribute to RNA research fields studying basic biochemical/molecular mechanisms of RNPs as diagnostic markers and therapeutic targets for treating human diseases.

Dr. Je-Hyun Yoon
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • RNA-binding protein
  • RNA localization
  • noncoding RNA
  • mRNA decay
  • mRNA translation
  • splicing

Published Papers (1 paper)

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Research

15 pages, 2604 KiB  
Article
Accumulation of Mitochondrial RPPH1 RNA Is Associated with Cellular Senescence
by Ji Won Lee, Yoo Lim Chun, Ah Young Kim, Lawson T. Lloyd, Seungbeom Ko, Je-Hyun Yoon and Kyung-Won Min
Int. J. Mol. Sci. 2021, 22(2), 782; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22020782 - 14 Jan 2021
Cited by 9 | Viewed by 2309
Abstract
Post-transcriptional gene regulation is an important step in the regulation of eukaryotic gene expression. Subcellular compartmentalization of RNA species plays a crucial role in the control of mRNA turnover, spatial restriction of protein synthesis, and the formation of macromolecular complexes. Although long noncoding [...] Read more.
Post-transcriptional gene regulation is an important step in the regulation of eukaryotic gene expression. Subcellular compartmentalization of RNA species plays a crucial role in the control of mRNA turnover, spatial restriction of protein synthesis, and the formation of macromolecular complexes. Although long noncoding RNAs (lncRNAs) are one of the key regulators of post-transcriptional gene expression, it is not heavily studied whether localization of lncRNAs in subcellular organelles has functional consequences. Here, we report on mitochondrial lncRNAs whose expression fluctuates in the process of cellular senescence. One of the mitochondrial lncRNAs, RPPH1 RNA, is overexpressed and accumulates in mitochondria of senescent fibroblasts, possibly modulated by the RNA-binding protein AUF1. In addition, RPPH1 RNA overexpression promotes spontaneous replicative cellular senescence in proliferating fibroblasts. Using MS2 aptamer-based RNA affinity purification strategy, we identified putative target mRNAs of RPPH1 RNA and revealed that partial complementarity of RPPH1 RNA to its target mRNAs prevents those mRNAs decay in proliferating fibroblasts. Altogether, our results demonstrate the role of mitochondrial noncoding RNA in the regulation of mRNA stability and cellular senescence. Full article
(This article belongs to the Special Issue RNPs (Ribonucleoproteins) in Human Physiology and Disease Processes)
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