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Special Issue "Reactive Oxygen Species (ROS) Signaling in the Control of Cell Viability and Death"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 September 2021.

Special Issue Editor

Dr. Steffen Reinbothe
E-Mail Website
Guest Editor
Laboratory of Plant Molecular Genetics, Grenoble‐Alpes‐University, 38400 Grenoble, France
Interests: protein topogenesis; chloroplasts; endosymbiotic theory; plastid envelope protein import machineries; thylakoid membrane protein translocases
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Special Issue Information

Dear Colleagues,

Reactive oxygen species (ROS) comprise a family of related compounds that are found in both prokaryotes and eukaryotes. In animals, ROS have been implicated in the control of cell viability, disease and death. There is emerging evidence of the distinct roles of individual ROS depending on their site of production and physicochemical properties. For example, mitochondrial ROS are major effectors of antimicrobial immunity. Chloroplast-derived singlet oxygen, as one form of ROS, is presumed to be part of a genetically programmed cell death pathway in plants, and ROS also play important roles in plant–fungal interactions. Changes in the concentrations, sources and sinks of ROS have been reported to affect marine ecosystem dynamics. New molecular tools have been developed to measure ROS accumulation in vivo and define the plethora of mechanisms underlying ROS’ action in nature. It is the aim of this Special Issue to highlight these aspects.

Dr. Steffen Reinbothe
Guest Editor

Manuscript Submission Information

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Keywords

  • ROS production in prokaryotes and eukaryotes
  • Mitochondrial ROS and their mode of action
  • Chloroplast ROS and their functions
  • Role of ROS in controlling cell viability, aging, and disease
  • Cell death regulation by ROS
  • ROS dynamics in organismic interactions

Published Papers (1 paper)

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Review

Open AccessReview
The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies
Int. J. Mol. Sci. 2021, 22(9), 4642; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094642 - 28 Apr 2021
Viewed by 190
Abstract
Living species are continuously subjected to all extrinsic forms of reactive oxidants and others that are produced endogenously. There is extensive literature on the generation and effects of reactive oxygen species (ROS) in biological processes, both in terms of alteration and their role [...] Read more.
Living species are continuously subjected to all extrinsic forms of reactive oxidants and others that are produced endogenously. There is extensive literature on the generation and effects of reactive oxygen species (ROS) in biological processes, both in terms of alteration and their role in cellular signaling and regulatory pathways. Cells produce ROS as a controlled physiological process, but increasing ROS becomes pathological and leads to oxidative stress and disease. The induction of oxidative stress is an imbalance between the production of radical species and the antioxidant defense systems, which can cause damage to cellular biomolecules, including lipids, proteins and DNA. Cellular and biochemical experiments have been complemented in various ways to explain the biological chemistry of ROS oxidants. However, it is often unclear how this translates into chemical reactions involving redox changes. This review addresses this question and includes a robust mechanistic explanation of the chemical reactions of ROS and oxidative stress. Full article
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