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Special Issue "Redox Homeostasis in Pulmonary Disorders"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 28 February 2021.

Special Issue Editor

Dr. Kumuda C Das
Guest Editor
Department of Internal Medicine, School of Medicine Texas Tech University Health Sciences Center, Lubbock, Texas 790430, USA
Interests: Lung injury and repair; Oxygen Toxicity in the lung; Pulmonary Mitochondrial dysfunction in hyperoxia; Redox signaling in lung injury and inflammation; Bronchopulmonary dysplasia; Oxidative lung diseases and molecular mechanisms

Special Issue Information

The lung is the only organ that directly communicates with the environment due to inhalation of ambient air for oxygenation. Although oxygen breathing is the very essence of living, oxygen is a major oxidizing agent in the body that oxidizes various biological molecules. Additionally, metabolism of oxygen in the pulmonary mitochondria produces reactive oxygen species that are potent oxidizers as well. Along with oxygen, we also breathe pollutants, allergens, both biological and chemical, and other toxic environmental particulates and gases. Further, the lung directly receives 20–21% oxygen in its alveoli compared to other organs in the body in which oxygen levels vary from 2% to 10%. Thus, the lung is designed to withstand significant oxidative insult compared to other organs. However, chronic exposure of the lung to various pathogens, toxic chemicals, allergens, and toxic gases promotes pulmonary disorders due to loss of redox homeostasis, resulting in enhanced pulmonary oxidative burden. The focus of this Special Issue is to present cutting-edge research in our current understanding of the impact of redox homeostasis in initiation and propagation of pulmonary disorders and the underlying cellular and molecular signaling mechanism associated with breathing of oxygen, environmental pollutants, allergens, microorganisms, and its impact on pulmonary defense system to lessen this chronic environmental insult. Further, the mechanisms by which loss of redox homeostasis might impact pathophysiology of the lung will also be addressed in this Special Issue.

Dr. Kumuda C Das
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • redox mechanisms
  • lung injury
  • COPD (chronic obstructive pulmonary disease)
  • ARDS (acute respiratory distress syndrome)
  • environmental toxicants and lung injury
  • lung mitochondria and redox
  • lung redox signaling
  • bronchopulmonary dysplasia (BPD)
  • lung inflammation and redox signaling

Published Papers

This special issue is now open for submission.
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