Dear Colleagues,

Oxidative stress, as a mechanism underlying many clinical conditions, is well known to play a crucial role in the development of renal disease as well as cardiovascular disease, diabetes, and cancers. However, the complex associations of oxidative status with hormones and inflammation are still far from being completely understood, since reciprocal and opposite influences can be exerted between these pathogenic factors. In addition, various nuclear factors and receptors involved in the regulation of antioxidant defense, nitric oxide production, inflammation, energy, and/or iron metabolism provide new targets for the prevention and treatment of renal disease and comorbid diseases.

Recent data have demonstrated that natural antioxidants can modulate oxidative stress and improve immune function. Thus, the role of compounds with antioxidant properties that promote health and counteract oxidative stress in the renal disease is worth investigating further. An exhaustive understanding of the role of the involvement of antioxidants in redox modulation would be useful for potential interventions and, subsequently, promoting health.

Therefore, we aim to publish a Special Issue which can cover a wide spectrum, from biological to translational studies, in the field of renal disorders.

This Special Issue will gather reviews and original data that focus on defining the following:

• Abnormalities in the antioxidant system in patients with renal diseases;
• Antioxidant therapeutics;
• Biomarkers and diagnostic methods in oxidative stress.

Dr. Keiko Hosohata
Guest Editor

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• reactive oxygen species (ROS)
• inflammation
• metabolic syndrome
• antioxidant response
• redox balance
• aging
• proinflammatory signals
• kidney