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Special Issue "Biomaterials, Neuroimmunology and Stem Cells for Repair Strategies in the Central Nervous System"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 31 January 2022.

Special Issue Editors

Prof. Dr. Zin Z. Khaing
E-Mail Website
Guest Editor
Department of Neurological Surgery, University of Washington, Brotman Baty Institute for Precision Medicine, Institute for Stem Cell & Regenerative Medicine, Washington, USA
Interests: neurodegenerative diseases; neuroinflammation; stem cells; spinal cord injury; engineered biomaterials
Prof. Dr. Stephanie Seidlits
E-Mail Website
Guest Editor
Department of Bioengineering, University of California Los Angeles, Los Angeles, CA, USA

Special Issue Information

Dear Colleagues,

Advances in stem cell biology and the development of novel biomaterials have changed the landscape of repair strategies for the central nervous system. Biomaterials made from synthetic as well as natural based materials applied to the central nervous system with engineering design components with specialized topography, pore size and bioactive molecules have been explored. Stem cells, either alone or in combination with biomaterials, have also been applied to promote the regeneration of brain and spinal cord tissues. It is becoming clear is that the neuroimmune system will likely play a critical role in the successful integration of exogenous biomaterials and stem cells, either alone or in combination, as part of a repair strategy.

In this Special Issue, focusing on the neuroimmune reaction to biomaterials and stem cells for CNS repair, we invite authors to contribute their original research articles, reviews and opinion letters.

Prof. Dr. Zin Z. Khaing
Prof. Dr. Stephanie Seidlits
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • central nervous system
  • biomaterials
  • stem cells
  • neuroimmunology

Published Papers (1 paper)

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Post-Stroke Timing of ECM Hydrogel Implantation Affects Biodegradation and Tissue Restoration
Int. J. Mol. Sci. 2021, 22(21), 11372; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms222111372 - 21 Oct 2021
Viewed by 338
Extracellular matrix (ECM) hydrogel promotes tissue regeneration in lesion cavities after stroke. However, a bioscaffold’s regenerative potential needs to be considered in the context of the evolving pathological environment caused by a stroke. To evaluate this key issue in rats, ECM hydrogel was [...] Read more.
Extracellular matrix (ECM) hydrogel promotes tissue regeneration in lesion cavities after stroke. However, a bioscaffold’s regenerative potential needs to be considered in the context of the evolving pathological environment caused by a stroke. To evaluate this key issue in rats, ECM hydrogel was delivered to the lesion core/cavity at 7-, 14-, 28-, and 90-days post-stroke. Due to a lack of tissue cavitation 7-days post-stroke, implantation of ECM hydrogel did not achieve a sufficient volume and distribution to warrant comparison with the other time points. Biodegradation of ECM hydrogel implanted 14- and 28-days post-stroke were efficiently (80%) degraded by 14-days post-bioscaffold implantation, whereas implantation 90-days post-stroke revealed only a 60% decrease. Macrophage invasion was robust at 14- and 28-days post-stroke but reduced in the 90-days post-stroke condition. The pro-inflammation (M1) and pro-repair (M2) phenotype ratios were equivalent at all time points, suggesting that the pathological environment determines macrophage invasion, whereas ECM hydrogel defines their polarization. Neural cells (neural progenitors, neurons, astrocytes, oligodendrocytes) were found at all time points, but a 90-days post-stroke implantation resulted in reduced densities of mature phenotypes. Brain tissue restoration is therefore dependent on an efficient delivery of a bioscaffold to a tissue cavity, with 28-days post-stroke producing the most efficient biodegradation and tissue regeneration, whereas by 90-days post-stroke, these effects are significantly reduced. Improving our understanding of how the pathological environment influences biodegradation and the tissue restoration process is hence essential to devise engineering strategies that could extend the therapeutic window for bioscaffolds to repair the damaged brain. Full article
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